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The potential role of contraction-induced myokines in the regulation of metabolic function for the prevention and treatment of type 2 diabetes

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dc.contributor.author Carson, Brian P.
dc.date.accessioned 2017-06-30T09:04:24Z
dc.date.available 2017-06-30T09:04:24Z
dc.date.issued 2017
dc.identifier.uri http://hdl.handle.net/10344/5870
dc.description peer-reviewed en_US
dc.description.abstract Skeletal muscle represents the largest organ in the body, comprises 36–42% of body weight, and has recently been recognized as having an endocrine function. Proteins expressed and released by muscle that have autocrine, paracrine, and endocrine bioactivities have been termed myokines. It is likely that muscle contraction represents the primary stimulus for the synthesis and secretion of myokines to enable communication with other organs such as the liver, adipose tissue, brain, and auto-regulation of muscle metabolism. To date, several hundred myokines in the muscle secretome have been identified, a sub-population of which are specifically induced by skeletal muscle contraction. However, the bioactivity of many of these myokines and the mechanism through which they act has either not yet been characterized or remains poorly understood. Physical activity and exercise are recognized as a central tenet in both the prevention and treatment of type 2 diabetes (T2D). Recent data suggest humoral factors such as muscle-derived secretory proteins may mediate the beneficial effects of exercise in the treatment of metabolic diseases. This mini-review aims to summarize our current knowledge on the role of contraction-induced myokines in mediating the beneficial effects of physical activity and exercise in the prevention and treatment of T2D, specifically glucose and lipid metabolism. Future directions as to how we can optimize contraction-induced myokine secretion to inform exercise protocols for the prevention and treatment of T2D will also be discussed. en_US
dc.language.iso eng en_US
dc.publisher Frontiers Media en_US
dc.relation.ispartofseries Frontiers in Psychology;8, artilce 97
dc.relation.uri http://dx.doi.org/10.3389/fendo.2017.00097
dc.rights This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission. en_US
dc.subject exercise en_US
dc.subject myokines en_US
dc.subject muscle en_US
dc.subject endocrine en_US
dc.subject diabetes en_US
dc.title The potential role of contraction-induced myokines in the regulation of metabolic function for the prevention and treatment of type 2 diabetes en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.3389/fendo.2017.00097
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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