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Strategies for the discovery, identification and validation of milk protein-derived bioactive peptides

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Show simple item record Nongonierma, Alice B. Fitzgerald, Richard J. 2017-04-13T11:59:39Z 2017-04-13T11:59:39Z 2016
dc.description peer-reviewed en_US
dc.description.abstract Background: The workflow used for the discovery of novel milk protein-derived bioactive peptides (BAPs) has significantly evolved over the past number of years. Many of the approaches currently described in the literature for the study of milk protein-derived BAPs have taken similar routes as those conventionally used in drug discovery. However, because milk protein-derived BAPs are prepared from dietary sources and in a food-grade manner, they differ from drugs in that they are generally present in a complex mixture as opposed to drug active compounds which are generally synthetically produced, having a relatively high level of purity.Scope and approach: This review assesses the utilisation of drug discovery methods for the identification of novel milk protein-derived BAPs. Different methods relevant to drug discovery have already proven effective for the discovery of new BAPs from milk proteins.Key findings and conclusions: However, reversing the workflow, starting from peptide identification in vivo to in vitro screening followed by conventional drug discovery approaches may have several merits. These include (a) the design of more targeted studies, (b) the development of novel approaches for the generation of milk, protein hydrolysates and (c) the discovery of milk BAPs which may be bioavailable in humans. These BAPs may find applications in the commercial generation of dietary ingredients with health promoting effects in humans. (C) 2016 Elsevier Ltd. All rights reserved. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Trends in Food Science and Technology;50, pp. 26-43
dc.rights This is the author’s version of a work that was accepted for publication in Trends in Food Science and Technology. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Trends in Food Science and Technology, 50, pp. 26-43, en_US
dc.subject milk proteins en_US
dc.subject bioactive peptides en_US
dc.subject drug discovery en_US
dc.title Strategies for the discovery, identification and validation of milk protein-derived bioactive peptides en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US 2017-04-11T08:25:17Z
dc.description.version ACCEPTED
dc.identifier.doi 10.1016/j.tifs.2016.01.022
dc.contributor.sponsor EI en_US
dc.relation.projectid TC2013-0001 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1638848
dc.internal.copyrightchecked Yes
dc.identifier.journaltitle Trends In Food Science & Technology
dc.description.status peer-reviewed

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