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Milk protein-derived peptides induce 5-HT2C-mediated satiety,in vivo

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dc.contributor.author Schellekens, Harriët
dc.contributor.author Nongonierma, Alice B.
dc.contributor.author Clarke, Gerard
dc.contributor.author van Oeffelen, Wesley E.P.A.
dc.contributor.author Fitzgerald, Richard J.
dc.contributor.author Dinan, Timothy G.
dc.contributor.author Cryan, John F.
dc.date.accessioned 2017-04-13T11:14:43Z
dc.date.available 2017-04-13T11:14:43Z
dc.date.issued 2014
dc.identifier.uri http://hdl.handle.net/10344/5711
dc.description peer-reviewed en_US
dc.description.abstract This study investigates the ability of milk protein-derived peptides to specifically activate the serotonin 2C (5-HT2C) receptor, a key receptor in central regulation of food intake. A dose dependent 5-HT2C receptor activation by the 1 kDa ultrafiltration permeates of a sodium caseinate (NaCNH-1 kDa permeate) and a whey protein hydrolysate (WPH-1 kDa permeate) was demonstrated using an intracellular calcium mobilization assay in human embryonic kidney (Hek) cells expressing the 5-HT2C receptor. Both samples activated the 5-HT2C but not the 5-HT2A and 5-HT2B receptors. NaCNH-1 kDa permeate significantly (p < 0.01) reduced cumulative food intake when administered to male mice (C57Bl/6) by intraperitoneal injection at 500 mg kg-1 body weight. In contrast, no effect of WPH-1 kDa permeate could be seen on food intake in vivo. These results demonstrate the promising appetite-suppressing potential of NaCN-derived peptides, targeting the 5-HT2C receptor. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries International Dairy Journal;38, 1, pp. 55-64
dc.relation.uri http://dx.doi.org/10.1016/j.idairyj.2014.04.004
dc.rights This is the author’s version of a work that was accepted for publication in International Dairy Journal. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in International Dairy Journal, 2014, 38 (1), pp. 55-64, http://dx.doi.org/10.1016/j.idairyj.2014.04.004 en_US
dc.subject 5-HT2C serotonin receptors en_US
dc.subject amino-acids profiles en_US
dc.subject food intake en_US
dc.subject alpha-lactalbumin en_US
dc.title Milk protein-derived peptides induce 5-HT2C-mediated satiety,in vivo en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2017-04-10T18:21:29Z
dc.description.version ACCEPTED
dc.identifier.doi 10.1016/j.idairyj.2014.04.004
dc.contributor.sponsor EI en_US
dc.relation.projectid TC2013-0001 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1573907
dc.internal.copyrightchecked Yes
dc.identifier.journaltitle International Dairy Journal
dc.description.status peer-reviewed


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