dc.contributor.author |
Schellekens, Harriët |
|
dc.contributor.author |
Nongonierma, Alice B. |
|
dc.contributor.author |
Clarke, Gerard |
|
dc.contributor.author |
van Oeffelen, Wesley E.P.A. |
|
dc.contributor.author |
Fitzgerald, Richard J. |
|
dc.contributor.author |
Dinan, Timothy G. |
|
dc.contributor.author |
Cryan, John F. |
|
dc.date.accessioned |
2017-04-13T11:14:43Z |
|
dc.date.available |
2017-04-13T11:14:43Z |
|
dc.date.issued |
2014 |
|
dc.identifier.uri |
http://hdl.handle.net/10344/5711 |
|
dc.description |
peer-reviewed |
en_US |
dc.description.abstract |
This study investigates the ability of milk protein-derived peptides to specifically activate the serotonin 2C (5-HT2C) receptor, a key receptor in central regulation of food intake. A dose dependent 5-HT2C receptor activation by the 1 kDa ultrafiltration permeates of a sodium caseinate (NaCNH-1 kDa permeate) and a whey protein hydrolysate (WPH-1 kDa permeate) was demonstrated using an intracellular calcium mobilization assay in human embryonic kidney (Hek) cells expressing the 5-HT2C receptor. Both samples activated the 5-HT2C but not the 5-HT2A and 5-HT2B receptors. NaCNH-1 kDa permeate significantly (p < 0.01) reduced cumulative food intake when administered to male mice (C57Bl/6) by intraperitoneal injection at 500 mg kg-1 body weight. In contrast, no effect of WPH-1 kDa permeate could be seen on food intake in vivo. These results demonstrate the promising appetite-suppressing potential of NaCN-derived peptides, targeting the 5-HT2C receptor. |
en_US |
dc.language.iso |
eng |
en_US |
dc.publisher |
Elsevier |
en_US |
dc.relation.ispartofseries |
International Dairy Journal;38, 1, pp. 55-64 |
|
dc.relation.uri |
http://dx.doi.org/10.1016/j.idairyj.2014.04.004 |
|
dc.rights |
This is the author’s version of a work that was accepted for publication in International Dairy Journal. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in International Dairy Journal, 2014, 38 (1), pp. 55-64, http://dx.doi.org/10.1016/j.idairyj.2014.04.004 |
en_US |
dc.subject |
5-HT2C serotonin receptors |
en_US |
dc.subject |
amino-acids profiles |
en_US |
dc.subject |
food intake |
en_US |
dc.subject |
alpha-lactalbumin |
en_US |
dc.title |
Milk protein-derived peptides induce 5-HT2C-mediated satiety,in vivo |
en_US |
dc.type |
info:eu-repo/semantics/article |
en_US |
dc.type.supercollection |
all_ul_research |
en_US |
dc.type.supercollection |
ul_published_reviewed |
en_US |
dc.date.updated |
2017-04-10T18:21:29Z |
|
dc.description.version |
ACCEPTED |
|
dc.identifier.doi |
10.1016/j.idairyj.2014.04.004 |
|
dc.contributor.sponsor |
EI |
en_US |
dc.relation.projectid |
TC2013-0001 |
en_US |
dc.rights.accessrights |
info:eu-repo/semantics/openAccess |
en_US |
dc.internal.rssid |
1573907 |
|
dc.internal.copyrightchecked |
Yes |
|
dc.identifier.journaltitle |
International Dairy Journal |
|
dc.description.status |
peer-reviewed |
|