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The use of ACT as an educational tool for examining the spread of antibiotic resistance

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dc.contributor.author Ryan, Michael P.
dc.contributor.author Adley, Catherine C.
dc.contributor.author Armshaw, Patricia
dc.contributor.author Pembroke, Tony J.
dc.date.accessioned 2017-04-10T15:15:20Z
dc.date.available 2017-04-10T15:15:20Z
dc.date.issued 2015
dc.identifier.isbn 978-84-942134-7-2
dc.identifier.uri http://hdl.handle.net/10344/5681
dc.description peer-reviewed en_US
dc.description.abstract The free availability of online software to undertake molecular evolutionary analysis coupled with the free availability of large amounts of sequence data has made the analysis of the spread of antibiotic resistance determinants amenable in an educational context. Software such as ACT (Artemis Comparison Tool) [1] can be utilised to extract useful evolutionary information from sequence databases with a focus on the dissemination of antibiotic resistance determinants. The utility of this resource is illustrated here using the SXT/R391 family of Integrating Conjugative Elements (ICE). These ICE s contain multiple antibiotic resistance determinants [2]. Using a stepwise tutorial with ACT, the elements are examined showing the utility of this software for such analysis in an evolutionary context. These examples are aimed at demonstrating the utility of the software for undergraduate and early postgraduate students.  en_US
dc.language.iso eng en_US
dc.publisher Formatex en_US
dc.relation.ispartofseries The Battle Against Microbial Pathogens: Basic Science, Technological Advances and Educational Programs. Méndez-Vilas, A (ed);pp. 1003-1009
dc.subject ACT en_US
dc.subject WebACT en_US
dc.subject genome comparison en_US
dc.title The use of ACT as an educational tool for examining the spread of antibiotic resistance en_US
dc.type info:eu-repo/semantics/bookPart en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2017-04-06T15:46:18Z
dc.description.version PUBLISHED
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2644406
dc.internal.copyrightchecked Yes
dc.description.status Peer reviewed


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