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Carrier particle design for stabilization and isolation of drug nanoparticles

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dc.contributor.author Tierney, Teresa B.
dc.contributor.author Bodnár, Katalin
dc.contributor.author Rasmuson, Åke C.
dc.contributor.author Hudson, Sarah P.
dc.date.accessioned 2017-01-04T14:28:23Z
dc.date.issued 2017
dc.identifier.uri http://hdl.handle.net/10344/5426
dc.description peer-reviewed en_US
dc.description.abstract Nanoparticles of poorly water-soluble drugs were prepared in suspension via antisolvent precipitation in order to improve their dissolution behaviour. Insoluble, surface-functionalized, micron-range, clay carrier particles were employed for the dual purpose of stabilizing the nanoparticles in suspended state, and facilitating their unhindered isolation to solid state; often a challenging step in nanoparticle production. The carrier particles, which were functionalized with an optimal level of cationic polymer (protamine), attracted negatively-charged nanoparticles to their surface as a uniform and segregated nanoparticle layer, at drug loadings up to 9% w/w. By using carrier particles to stabilise the nanoparticles on their surface, the traditionally used solubilised nanosuspension stabilisers could be eliminated, thus avoiding time-consuming stabiliser screening tests. The carrier particle system facilitated stabilisation of nanoparticles in suspension, isolation of nanoparticles to the solid state via filtration, and preservation of fast nanoparticle-induced dissolution rates of the dried nanoparticle-carrier composites, indicating preservation of their high surface area during drying. The process was validated with two poorly water-soluble BCS Class II drugs, fenofibrate and mefenamic acid, both of which demonstrated negative surface charge in aqueous suspension. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries International Journal of Pharmaceutics;518 (1-2), pp. 111-118
dc.relation.uri http://dx.doi.org/10.1016/j.ijpharm.2016.11.045
dc.rights This is the author’s version of a work that was accepted for publication in International Journal of Pharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in International Journal of Pharmaceutics, 2017, 518 (1-2), pp. 111-118, http://dx.doi.org/10.1016/j.ijpharm.2016.11.045 en_US
dc.subject carrier particles en_US
dc.subject drug nanoparticles en_US
dc.subject bioavailability en_US
dc.subject antisolvent precipitation en_US
dc.subject filtration en_US
dc.subject dissolution rate en_US
dc.title Carrier particle design for stabilization and isolation of drug nanoparticles en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1016/j.ijpharm.2016.11.045
dc.contributor.sponsor IRC en_US
dc.contributor.sponsor SFI en_US
dc.date.embargoEndDate 2017-11-21
dc.embargo.terms 2017-11-21 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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