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Investigation of the particle growth of fenofibrate following antisolvent precipitation and freeze-drying

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dc.contributor.author Tierney, Teresa B.
dc.contributor.author Guo, Yina
dc.contributor.author Beloshapkin, Sergey
dc.contributor.author Rasmuson, Åke C.
dc.contributor.author Hudson, Sarah P.
dc.date.accessioned 2016-11-18T09:01:46Z
dc.date.available 2016-11-18T09:01:46Z
dc.date.issued 2015
dc.identifier.uri http://hdl.handle.net/10344/5351
dc.description peer-reviewed en_US
dc.description.abstract Submicron to small-micron-sized particles of the hydrophobic drug, fenofibrate, were prepared by controlled crystallization in order to influence its dissolution behavior. An antisolvent precipitation process successfully generated particles (200-300 nm) which matched the size and dissolution behavior of a commercial wet-milled formulation of the drug. Although the preparation of submicron-sized particles was straightforward, retaining their size in suspension and during isolation was a challenge. Additives were employed to temporarily stabilize the suspension, and extend the time window for isolation of the submicron particles. Precipitated particles were isolated primarily by immediate freeze-drying, but drying stresses were found to destabilize the fragile submicron system. The growth pathway of particles in suspension and during oven and freeze-drying were compared. Although the growth pathways appeared considerably different from a visual morphological perspective, an investigation of the electron diffraction patterns and the inner-particle surfaces showed that the growth pathways were the same: molecular addition by Ostwald ripening. The observed differences in the time-resolved particle morphologies were found to be a result of the freeze-drying process. en_US
dc.language.iso eng en_US
dc.publisher American Chemical Society en_US
dc.relation.ispartofseries Crystal Growth and Design;15 (1), pp. 5213-5222
dc.relation.uri http://dx.doi.org/10.1021/acs.cgd.5b00662
dc.rights © 2015 ACS This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal Title, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/acs.cgd.5b00662 en_US
dc.subject formulation en_US
dc.subject crystallization en_US
dc.title Investigation of the particle growth of fenofibrate following antisolvent precipitation and freeze-drying en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2016-11-18T08:50:03Z
dc.description.version ACCEPTED
dc.identifier.doi 10.1021/acs.cgd.5b00662
dc.contributor.sponsor IRC en_US
dc.contributor.sponsor ERC en_US
dc.contributor.sponsor Program for Research in Third-Level Institutions (PRTLI) Cycle 5 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1618915
dc.internal.copyrightchecked Yes
dc.identifier.journaltitle Crystal Growth & Design
dc.description.status peer-reviewed


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