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Influence of agitation on primary nucleation in stirred tank crystallizers

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dc.contributor.author Liu, Jin
dc.contributor.author Svärd, Michael
dc.contributor.author Rasmuson, Åke C.
dc.date.accessioned 2016-11-15T14:40:33Z
dc.date.available 2016-11-15T14:40:33Z
dc.date.issued 2015
dc.identifier.uri http://hdl.handle.net/10344/5343
dc.description peer-reviewed en_US
dc.description.abstract The influence of agitation on nucleation of butyl paraben and m-hydroxybenzoic acid polymorphs has been investigated through 330 cooling crystallization experiments. The induction time has been measured at different supersaturations and temperatures in three parallel jacketed vessels equipped with different overhead stirring agitators. In each case, the nucleating polymorph of m-hydroxybenzoic acid has been identified by infrared spectroscopy. The influences of agitation rate, impeller type, impeller diameter, impeller to bottom clearance, and the use of baffles have been investigated. A general trend in all of the experiments is that the induction time decreases with increasing agitation rate. Across all experiments with different fluid mechanics for the butyl paraben system, the induction time is correlated to the average energy dissipation rate raised to the power -0.3. It is shown that this dependence is consistent with a turbulent flow enhanced cluster coalescence mechanism. In experiments with m-hydroxybenzoic acid, the metastable form II was always obtained at higher nucleation driving force while both polymorphs were obtained at lower driving force. In the latter case, form I was obtained in the majority of experiments at low agitation rate (100 rpm) while form II was obtained in all experiments at higher agitation rate (>= 300 rpm). en_US
dc.language.iso eng en_US
dc.publisher American Chemical Society en_US
dc.relation.ispartofseries Crystal Growth and Design;15 (9), pp. 4177-4184
dc.relation.uri http://dx.doi.org/10.1021/cg501791q
dc.rights © Year ACS This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth and Design, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/cg501791q en_US
dc.subject hydroxybenzoic acid polymorphs en_US
dc.subject turbulent-flow en_US
dc.subject agglomeration kinetics en_US
dc.subject power-consumption en_US
dc.subject aqueous-solutions en_US
dc.subject fluid shear en_US
dc.subject model en_US
dc.title Influence of agitation on primary nucleation in stirred tank crystallizers en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2016-11-15T11:56:33Z
dc.description.version ACCEPTED
dc.identifier.doi 10.1021/cg501791q
dc.contributor.sponsor Swedish Research Council en_US
dc.contributor.sponsor SFI en_US
dc.relation.projectid 621-2010-5391 en_US
dc.relation.projectid 10/IN.1/B3038 en_US
dc.relation.projectid 12/RC2255 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1597838
dc.internal.copyrightchecked Yes
dc.identifier.journaltitle Crystal Growth & Design
dc.description.status peer-reviewed


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