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Colonisation with extended-spectrum beta-lactamase (ESBL) not detected in a prevalence study.

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Show simple item record O'Connor, Ciara Kiernan, Miranda G. Finnegan, Cathriona Powell, James Power, Lorraine O'Connell, Nuala H. Dunne, Colum P. 2016-11-15T09:33:56Z 2016
dc.description peer-reviewed en_US
dc.description.abstract Background The Mid-West of Ireland has higher than average national rates of invasive extended-spectrum beta-lactamase (ESBL) bloodstream infections and carbapenemase-producing Enterobacteriaceae (CPE), with increasing numbers of ESBL isolates detected in community-dwelling patients. Aims To conduct a point prevalence study in a convenience sample of the Mid-West population with the aim of determining the extent of ESBL colonisation Methods Utilising anonymised community stool samples that had completed routine analysis, we conducted a point prevalence study over a four-week period on all samples that met defined inclusion and exclusion criteria. Limited epidemiological data was recorded: (1) age of patient, (2) gender, (3) sender location. From these stool specimens, rectal swabs were inoculated (eSwab™ 480CE, Copan, Italy), which were subsequently cultured on selective chromogenic agar (Colorex™ ESBL). Culture plates were incubated aerobically at 37˚C for 24 hours. Results Of 195 samples processed, 58% (n=112) were from females. The median patient age was 62.4 years (range 20-94 years). 186 samples (95%) originated from general practitioner clinics. During the study period, only nine eligible stool samples were received from LTCF (6 public). From 195 Colorex™ ESBL chromogenic agar plates cultured, no ESBL-producing organisms were detected. Conclusions This community point prevalence study did not identify ESBL-colonisation despite high numbers of patients with invasive ESBL bloodstream infections presenting for admission in our institution. We believe this may be because of our small sample size. Data regarding antimicrobial exposure and other risk factors for ESBL-colonisation was also not available. We remain vigilant for ESBL-producing organisms. en_US
dc.language.iso eng en_US
dc.publisher Springer en_US
dc.relation.ispartofseries Irish Journal of Medical Science; 186 (3), pp. 723-727
dc.rights The original publication is available at en_US
dc.subject extended-spectrum beta-lactamase (ESBL)-producing enterobacteriaceae en_US
dc.subject Ireland en_US
dc.subject point prevalence study en_US
dc.subject rectal carriage en_US
dc.title Colonisation with extended-spectrum beta-lactamase (ESBL) not detected in a prevalence study. en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US 2016-11-15T08:56:53Z
dc.description.version ACCEPTED
dc.identifier.doi 10.1007/s11845-016-1505-8
dc.contributor.sponsor Irish Society of Clinical Microbiologists en_US 2017-09-24
dc.embargo.terms 2017-09-24 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1647876
dc.internal.copyrightchecked Yes
dc.identifier.journaltitle Irish journal of medical science
dc.description.status peer-reviewed

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