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Oiling-out or molten hydrate - liquid-liquid phase separation in the system vanillin-water

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Show simple item record Svärd, Michael Gracin, Sandra Rasmuson, Åke C. 2016-10-26T11:29:21Z 2016-10-26T11:29:21Z 2007
dc.description peer-reviewed en_US
dc.description.abstract Vanillin crystals in a saturated aqueous solution disappear and a second liquid phase emerges when the temperature is raised above 51°C. The phenomenon has been investigated with crystallization and equilibration experiments, using DSC, TGA, XRD and hot-stage microscopy for analysis. The new liquid solidifies on cooling, appears to melt at 51°C, and has a composition corresponding to a dihydrate. However, no solid hydrate can be detected by XRD, and it is shown that the true explanation is that a liquid-liquid phase separation occurs above 51°C where the vanillin-rich phase has a composition close to a dihydrate. To our knowledge, liquid-liquid phase separation has not previously been reported for the system vanillin-water, even though thousands of tonnes of vanillin are produced globally every year. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Journal of Pharmaceutical Sciences;96 (9), pp. 2390-2398
dc.rights This is the author’s version of a work that was accepted for publication in Journal of Pharmaceutical Sciences. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Journal of Pharmaceutical Scienes, 2012, 96, (9), pp. 2390-2398, en_US
dc.subject oiling out en_US
dc.subject polymorphism en_US
dc.subject pseudopolymorphism en_US
dc.subject hydrates/solvates en_US
dc.subject solubility en_US
dc.subject thermodynamics en_US
dc.subject solid state stability en_US
dc.subject phase separation en_US
dc.subject phase diagram en_US
dc.title Oiling-out or molten hydrate - liquid-liquid phase separation in the system vanillin-water en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US 2016-10-22T10:17:45Z
dc.description.version ACCEPTED
dc.identifier.doi 10.1002/jps.20899
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 2645201
dc.internal.copyrightchecked Yes
dc.identifier.journaltitle Journal Of Pharmaceutical Sciences
dc.description.status peer-reviewed

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