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Influence of solution thermal and structural history on the nucleation of m-hydroxybenzoic acid polymorphs

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dc.contributor.author Nordström, Fredrik
dc.contributor.author Svärd, Michael
dc.contributor.author Malmberg, Baldur
dc.contributor.author Rasmuson, Åke C.
dc.date.accessioned 2016-10-26T11:07:15Z
dc.date.available 2016-10-26T11:07:15Z
dc.date.issued 2012
dc.identifier.uri http://hdl.handle.net/10344/5297
dc.description peer-reviewed en_US
dc.description.abstract The influence of solution pretreatment on primary nucleation of m-hydroxybenzoic acid has been investigated through 550 cooling crystallization experiments. The metastable zone width has been determined at constant cooling rate, and the time and temperature of the preceding superheating step have been varied. m-Hydroxybenzoic acid has two polymorphs, and the influence of the polymorph used to prepare the solutions has also been investigated. There is an overall tendency in the experiments for the solution to exhibit a larger metastable zone width if it is superheated for a longer time and at a higher temperature, but under the investigated conditions this tendency is not very strong. The results show that the metastable form II preferentially crystallizes in all experiments and in particular when the solution has been more strongly superheated for several hours. However, when the time and/or the temperature of superheating is reduced, there is an increasing tendency to obtain the stable form I. This is most clearly found for solutions prepared by dissolving form I. When the solutions are prepared by dissolution of form II, this tendency is weaker in what appears to be a systematic way. It is hypothesized that, unless the solution is strongly superheated for several hours, it will contain for a significant period of time clusters of solute molecules that can retain some degree of structure from the dissolved crystal. This leads to ";memory" effects in the solution, which may influence subsequent nucleation. The work includes a comprehensive review of previous published work on the influence of thermal history on nucleation in solutions and melts. en_US
dc.language.iso eng en_US
dc.publisher American Chemical Society en_US
dc.relation.ispartofseries Crystal Growth and Design;12, (9), pp. 4340-4348
dc.relation.uri http://dx.doi.org/10.1021/cg3000312
dc.rights © Year ACS This document is the Accepted Manuscript version of a Published Work that appeared in final form in Crystal Growth and Design, 2012, 12(9), pp. 4340-4348 copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/cg3000312 en_US
dc.subject metastable zone width en_US
dc.subject supersaturated solutions en_US
dc.subject cluster formation en_US
dc.subject crystals en_US
dc.subject liquids en_US
dc.title Influence of solution thermal and structural history on the nucleation of m-hydroxybenzoic acid polymorphs en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2016-10-22T10:19:12Z
dc.description.version ACCEPTED
dc.identifier.doi 10.1021/cg3000312
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1414463
dc.internal.copyrightchecked Yes
dc.identifier.journaltitle Crystal Growth & Design
dc.description.status peer-reviewed


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