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Thermodynamics of risperidone and solubility in pure organic solvents

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dc.contributor.author Mealey, Donal
dc.contributor.author Svärd, Michael
dc.contributor.author Rasmuson, Åke C.
dc.date.accessioned 2016-10-25T15:04:05Z
dc.date.available 2016-10-25T15:04:05Z
dc.date.issued 2014
dc.identifier.uri http://hdl.handle.net/10344/5292
dc.description peer-reviewed en_US
dc.description.abstract The solid-liquid solubility of the thermodynamically stable form I of the drug risperidone has been determined by a gravimetric method in nine pure organic solvents in the temperature range 278.15-323.15 K. The melting temperature and associated enthalpy of fusion of risperidone form I has been determined by differential scanning calorimetry (DSC) to be 442.38 K and 43.94 kJ mol(-1), respectively. The heat capacity of the solid form I and the melt have been determined over a range of temperatures by temperature-modulated DSC, and extrapolated data has been used to calculate the Gibbs energy, enthalpy and entropy of fusion from ambient temperature up to the melting point. The ideal solubility within a Raoult's law framework is obtained from the Gibbs energy of fusion, and the solution activity coefficient at equilibrium in the nine solvents quantified. Solutions in all solvents exhibit positive deviation from Raoult's law, with the highest solubility (closest to ideality) in toluene, an aprotic apolar solvent. The solubility curves plotted in a van't Hoff graph show non-linear behaviour and are well-approximated by a second order polynomial. (C) 2014 Elsevier B.V. All rights reserved. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Fluid Phase Equilibria;375, pp. 73-79
dc.relation.uri http://dx.doi.org/10.1016/j.fluid.2014.04.028
dc.rights This is the author’s version of a work that was accepted for publication in Fluid Phase Equilibria. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Fluid Phase Equilibria, 375, pp. 73-79, http://dx.doi.org/10.1016/j.fluid.2014.04.028 en_US
dc.subject solubility en_US
dc.subject thermodynamics en_US
dc.subject ideality en_US
dc.subject activity coefficient en_US
dc.subject polymorphs en_US
dc.subject transition en_US
dc.subject heat en_US
dc.title Thermodynamics of risperidone and solubility in pure organic solvents en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2016-10-22T11:13:21Z
dc.description.version ACCEPTED
dc.identifier.doi 10.1016/j.fluid.2014.04.028
dc.contributor.sponsor SFI en_US
dc.contributor.sponsor Swedish Research Council en_US
dc.relation.projectid 10/IN.1/B3038 en_US
dc.relation.projectid 621-2010-5391 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1573930
dc.internal.copyrightchecked Yes
dc.description.status peer-reviewed


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