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SXT/R391 ICE elements encode a novel trap-door strategy for mobile element escape.

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dc.contributor.author Ryan, Michael P.
dc.contributor.author Armshaw, Patricia
dc.contributor.author Pembroke, Tony J.
dc.date.accessioned 2016-07-05T15:20:20Z
dc.date.available 2016-07-05T15:20:20Z
dc.date.issued 2016
dc.identifier.uri http://hdl.handle.net/10344/5103
dc.description peer-reviewed en_US
dc.description.abstract                            Integrative Conjugative Elements (ICEs) are a class of bacterial mobile elements that have the ability to mediate their own integration, excision and transfer from one host genome to another by a mechanism of site-specific recombination, self-circularisation and conjugative transfer. Members of the SXT/R391 ICE family of enterobacterial mobile genetic elements display an unusual UV-inducible sensitisation function which results in stress induced killing of bacterial cells harbouring the ICE. This sensitisation has been shown to be associated with a stress induced overexpression of a mobile element encoded conjugative transfer gene, orf43, a traV homolog. This results in cell lysis and release of a circular form of the ICE. Induction of this novel system may allow transfer of an ICE, enhancing its survival potential under conditions not conducive to conjugative transfer. en_US
dc.language.iso eng en_US
dc.publisher Frontiers Media en_US
dc.relation.ispartofseries Frontiers in Microbiology;7, article 829
dc.relation.uri http://journal.frontiersin.org/article/10.3389/fmicb.2016.00829/full
dc.rights This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission en_US
dc.subject SXT/R391 ICE en_US
dc.subject UV sensitisation en_US
dc.subject integrative conjugative element en_US
dc.subject mobile element en_US
dc.subject bacteria en_US
dc.title SXT/R391 ICE elements encode a novel trap-door strategy for mobile element escape. en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2016-07-05T15:15:56Z
dc.description.version PUBLISHED
dc.identifier.doi 10.3389/fmicb.2016.00829/full
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1639589
dc.internal.rssid 2644396
dc.internal.rssid 1643132
dc.internal.copyrightchecked Yes
dc.description.status peer-reviewed


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