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The first reported case of Burkholderia contaminans in patients with cystic fibrosis in Ireland: from the Sargasso Sea to Irish children

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dc.contributor.author Power, Rachel
dc.contributor.author Linnane, Barry
dc.contributor.author Martin, Ruth
dc.contributor.author Power, Noelle
dc.contributor.author Harnett, Peig
dc.contributor.author Casserly, Brian
dc.contributor.author O'Connell, Nuala H.
dc.contributor.author Dunne, Colum P.
dc.date.accessioned 2016-06-07T10:39:49Z
dc.date.available 2016-06-07T10:39:49Z
dc.date.issued 2016
dc.identifier.citation Rachel Power, Barry Linnane, Ruth Martin, Noelle Power, Peig Harnett, Brian Casserly, Nuala H. O'Connell, Colum P. Dunne (2016) 'The first reported case of Burkholderia contaminans in patients with cystic fibrosis in Ireland: From the Sargasso Sea to Irish Children'. Bmc Pulmonary Medicine, 16 (1). en_US
dc.identifier.uri http://hdl.handle.net/10344/5070
dc.description peer-reviewed en_US
dc.description.abstract Background: Burkholderia contaminans is an emerging pathogen in the cystic fibrosis (CF) setting. Included in the Burkholderia cepacia complex (Bcc), B. contaminans is a Gram negative, motile, obligate aerobe previously classified as a pseudomonad. Previous reports have described B. contaminans isolation from patients in Portugal, Switzerland, Spain, Argentina and the USA. This, however, is the first report relating to B. contaminans affecting Irish patients with CF, initially detected in a paediatric setting. Case presentation: Burkholderia contaminans was identified in the routine analysis of sputum from a fourteen year old boy, at his annual review and subsequently from the sputum from his 19 year old brother. RecA gene sequencing and pulsed field gel electrophoresis (PFGE) were unable to distinguish between the isolates, which demonstrated with susceptibility to ciprofloxacin, cotrimoxazole, meropenem, pipercillin/tazobactam and ceftazidime. Both isolates were resistant to aztreonam, with reduced susceptibility to tobramycin. Following treatment with intravenous meropenem and ceftazidime, oral ciprofloxacin and nebulised tobramycin for 6 weeks, sputum specimens from both patients were negative for B. contaminans. No other member of the local CF cohort proved positive. Conclusions: Bcc bacteria are associated with poor prognosis in CF and decreased life expectancy, specifically leading to a more rapid decline in lung function and, in some cases, to a fatal necrotizing pneumonia known as the “cepacia syndrome”. Some species exhibit innate resistance to multiple antimicrobial agents and their transmission rate can be high in susceptible patients. In that context, we describe the first incidence of CF-related B. contaminans in Ireland and its successful eradication from two patients, one paediatric, using an aggressive antimicrobial regimen. en_US
dc.language.iso eng en_US
dc.publisher BioMed Central en_US
dc.subject Burkholderia contaminans en_US
dc.subject cystic fibrosis en_US
dc.subject first incidence en_US
dc.subject Ireland en_US
dc.subject case report en_US
dc.title The first reported case of Burkholderia contaminans in patients with cystic fibrosis in Ireland: from the Sargasso Sea to Irish children en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2016-06-07T10:21:37Z
dc.description.version PUBLISHED
dc.identifier.doi 10.1186/s12890-016-0219-z
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1633632
dc.internal.rssid 1642466
dc.internal.copyrightchecked Yes
dc.description.status peer-reviewed


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