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A prototype antifungal contact lens

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dc.contributor.author Ciolino, Joseph B.
dc.contributor.author Hudson, Sarah P.
dc.contributor.author Mobbs, Ashley N.
dc.contributor.author Hoare, Todd R.
dc.contributor.author Iwata, Naomi G.
dc.contributor.author Fink, Gerald R.
dc.contributor.author Kohane, Daniel S.
dc.date.accessioned 2016-04-14T15:42:00Z
dc.date.available 2016-04-14T15:42:00Z
dc.date.issued 2011
dc.identifier.uri http://hdl.handle.net/10344/5020
dc.description peer-reviewed en_US
dc.description.abstract PURPOSE. To design a contact lens to treat and prevent fungal ocular infections.METHODS. Curved contact lenses were created by encapsulating econazole-impregnated poly(lactic-co-glycolic) acid (PLGA) films in poly(hydroxyethyl methacrylate) (pHEMA) by ultraviolet photopolymerization. Release studies were conducted in phosphate-buffered saline at 37 degrees C with continuous shaking. The contact lenses and their release media were tested in an antifungal assay against Candida albicans. Cross sections of the pre- and postrelease contact lenses were characterized by scanning electron microscopy and by Raman spectroscopy.RESULTS. Econazole-eluting contact lenses provided extended antifungal activity against Candida albicans fungi. Fungicidal activity varied in duration and effectiveness depending on the mass of the econazole-PLGA film encapsulated in the contact lens.CONCLUSIONS. An econazole-eluting contact lens could be used as a treatment for fungal ocular infections. (Invest Ophthalmol Vis Sci. 2011;52:6286-6291) DOI:10.1167/iovs.10-6935 en_US
dc.language.iso eng en_US
dc.publisher Association for Research in Vision and Ophthalmology (ARVO) en_US
dc.relation.ispartofseries Investigative Ophthalmology and Visual Science;52 (9), pp. 6286-6291
dc.subject fungal keratitis en_US
dc.subject drug-delivery en_US
dc.subject management en_US
dc.subject fusarium en_US
dc.subject susceptibility en_US
dc.subject ganciclovir en_US
dc.subject temperature en_US
dc.subject outbreak en_US
dc.title A prototype antifungal contact lens en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2016-04-14T15:33:01Z
dc.description.version PUBLISHED
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1148028
dc.internal.copyrightchecked Yes
dc.description.status peer-reviewed


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