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Expanding the biotechnology potential of lactobacilli through comparative genomics of 213 strains and associated genera

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dc.contributor.author Sun, Zhihong
dc.contributor.author Harris, Hugh M. B.
dc.contributor.author McCann, Angela
dc.contributor.author Guo, Chenyi
dc.contributor.author Argimon, Silvia
dc.contributor.author Zhang, Wenyi
dc.contributor.author Yang, Xianwei
dc.contributor.author Jeffrey, Ian B.
dc.contributor.author Cooney, Jakki C.
dc.contributor.author Kagawa, Todd F.
dc.contributor.author Liu, Wenjun
dc.contributor.author Song, Yuqin
dc.contributor.author Salvetti, Elisa
dc.contributor.author Wrobel, Agneszka
dc.contributor.author Rasinkangas, Pia
dc.contributor.author Parkhill, Julian
dc.contributor.author Rea, Mary C.
dc.contributor.author O'Sullivan, Orla
dc.contributor.author Ritari, Jarmo
dc.contributor.author Douillard, Francois P.
dc.contributor.author Ross, Paul R.
dc.contributor.author Yang, Ruifu
dc.contributor.author Briner, Alexandra E.
dc.contributor.author Felis, Giovanna E.
dc.contributor.author de Vos, Willem M.
dc.contributor.author Barrangou, Rodolphe
dc.contributor.author Klaenhammer, Todd R.
dc.contributor.author Caufield, Page W.
dc.contributor.author Cui, Yujun
dc.contributor.author Zhang, Heping
dc.contributor.author O'Toole, Paul W.
dc.date.accessioned 2016-04-14T11:51:30Z
dc.date.available 2016-04-14T11:51:30Z
dc.date.issued 2015
dc.identifier.citation Sun, ZH,Harris, HMB,McCann, A,Guo, CY,Argimon, S,Zhang, WY,Yang, XW,Jeffery, IB,Cooney, JC,Kagawa, TF,Liu, WJ,Song, YQ,Salvetti, E,Wrobel, A,Rasinkangas, P,Parkhill, J,Rea, MC,O'Sullivan, O,Ritari, J,Douillard, FP,Ross, RP,Yang, RF,Briner, AE,Felis, GE,de Vos, WM,Barrangou, R,Klaenhammer, TR,Caufield, PW,Cui, YJ,Zhang, HP,O'Toole, PW (2015) 'Expanding the biotechnology potential of lactobacilli through comparative genomics of 213 strains and associated genera'. Nature Communications, 6 . en_US
dc.identifier.uri http://hdl.handle.net/10344/5019
dc.description peer-reviewed en_US
dc.description.abstract Lactobacilli are a diverse group of species that occupy diverse nutrient-rich niches associated with humans, animals, plants and food. They are used widely in biotechnology and food preservation, and are being explored as therapeutics. Exploiting lactobacilli has been complicated by metabolic diversity, unclear species identity and uncertain relationships between them and other commercially important lactic acid bacteria. The capacity for biotransformations catalysed by lactobacilli is an untapped biotechnology resource. Here we report the genome sequences of 213 Lactobacillus strains and associated genera, and their encoded genetic catalogue for modifying carbohydrates and proteins. In addition, we describe broad and diverse presence of novel CRISPR-Cas immune systems in lactobacilli that may be exploited for genome editing. We rationalize the phylogenomic distribution of host interaction factors and bacteriocins that affect their natural and industrial environments, and mechanisms to withstand stress during technological processes. We present a robust phylogenomic framework of existing species and for classifying new species. en_US
dc.language.iso eng en_US
dc.publisher Nature Publishing Group en_US
dc.relation.ispartofseries Nature Communications;6: 8322
dc.relation.uri http://dx.doi.org/10.1038/ncomms9322
dc.subject lactic-acid bacteria en_US
dc.subject crispr-cas systems en_US
dc.subject multiple sequence alignment en_US
dc.subject gram-positive bacteria en_US
dc.subject phylogenetic analysis en_US
dc.subject genus lactobacillus en_US
dc.subject molecular-cloning en_US
dc.subject protein en_US
dc.subject probiotics en_US
dc.title Expanding the biotechnology potential of lactobacilli through comparative genomics of 213 strains and associated genera en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2016-04-14T11:25:03Z
dc.description.version PUBLISHED
dc.identifier.doi 10.1038/ncomms9322
dc.contributor.sponsor SFI en_US
dc.contributor.sponsor ERC en_US
dc.contributor.sponsor US National Institute of Dental and Craniofacial Research en_US
dc.contributor.sponsor National Natural Science Foundation of China en_US
dc.contributor.sponsor Academy of Finland en_US
dc.relation.projectid SFI/12/RC/2273 en_US
dc.relation.projectid 250172 en_US
dc.relation.projectid R01DE019455 en_US
dc.relation.projectid 07-IN.1-B1780 en_US
dc.relation.projectid 31430066 en_US
dc.relation.projectid 2015CB554202 en_US
dc.relation.projectid 141140 en_US
dc.relation.projectid 252123 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1599515
dc.internal.copyrightchecked Yes
dc.description.status peer-reviewed


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