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The biocompatibility of mesoporous silicates

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Show simple item record Hudson, Sarah P. Padera, Robert F Langer, Robert Kohane, Daniel S. 2016-04-13T15:27:45Z 2016-04-13T15:27:45Z 2008
dc.identifier.citation Hudson, SP; Padera, RF; Langer, R; Kohane, DS (2008) 'The biocompatibility of mesoporous silicates'. BIOMATERIALS, 29 (30):4045-4055. en_US
dc.description peer-reviewed en_US
dc.description.abstract Micro- and nano-mesoporous silicate particles are considered potential drug delivery systems because of their ordered pore structures, large surface areas and the ease with which they can be chemically modified. However, few cytotoxicity or biocompatibility studies have been reported, especially when silicates are administered in the quantities necessary to deliver low-potency drugs. The biocompatibility of mesoporous silicates of particle sizes similar to 150 nm, similar to 800 nm and similar to 4 mu m and pore sizes of 3 nm, 7 nm and 16 nm, respectively, is examined here. In vitro, mesoporous silicates showed a significant degree of toxicity at high concentrations with mesothelial cells. Following subcutaneous injection of silicates in rats, the amount of residual material decreased progressively over 3 months, with good biocompatibility on histology at all time points. In contrast, intra-peritoneal and intra-venous injections in mice resulted in death or euthanasia. No toxicity was seen with subcutaneous injection of the same particles in mice. Microscopic analysis of the lung tissue of the mice indicated that death may be due to thrombosis. Although local tissue reaction to mesoporous silicates was benign, they caused severe systemic toxicity. This toxicity might be mitigated by modification of the materials. (C) 2008 Elsevier Ltd. All rights reserved. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Biomaterials;29 (30), pp. 4045-4055
dc.rights This is the author’s version of a work that was accepted for publication in Biomaterials. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Biomaterials, 29 (30), pp. 4045-4055, en_US
dc.subject silicate en_US
dc.subject mesoporous en_US
dc.subject biocompatibility en_US
dc.subject drug delivery en_US
dc.subject controlled drug release en_US
dc.subject drug delivery system en_US
dc.title The biocompatibility of mesoporous silicates en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US 2016-04-13T15:17:02Z
dc.description.version ACCEPTED
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1128013
dc.internal.copyrightchecked Yes
dc.description.status peer-reviewed

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