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A preliminary study examining the binding capacity of akkermansia muciniphila and desulfovibrio spp., to colonic mucin in health and ulcerative colitis

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dc.contributor.author Earley, Helen
dc.contributor.author Lennon, Grainne
dc.contributor.author Balfe, Áine
dc.contributor.author Kilcoyne, Michelle
dc.contributor.author Clyne, Marguerite
dc.contributor.author Joshi, Lokesh
dc.contributor.author Carrington, Stephen
dc.contributor.author Martin, Sean T.
dc.contributor.author Coffey, Calvin J.
dc.contributor.author Winter, Desmond C.
dc.contributor.author O'Connell, Ronan P.
dc.date.accessioned 2016-03-30T14:08:49Z
dc.date.available 2016-03-30T14:08:49Z
dc.date.issued 2015
dc.identifier.uri http://hdl.handle.net/10344/4991
dc.description peer-reviewed en_US
dc.description.abstract Akkermansia muciniphila and Desulfovibrio spp. are commensal microbes colonising the mucus gel layer of the colon. Both species have the capacity to utilise colonic mucin as a substrate. A. muciniphila degrades colonic mucin, while Desulfovibrio spp. metabolise the sulfate moiety of sulfated mucins. Altered abundances of these microorganisms have been reported in ulcerative colitis (UC). However their capacity to bind to human colonic mucin, and whether this binding capacity is affected by changes in mucin associated with UC, remain to be defined. en_US
dc.language.iso eng en_US
dc.publisher Public Library of Science en_US
dc.relation.ispartofseries PloS ONE;10 (10), e0135280
dc.subject bacteria en_US
dc.subject Akkermansia muciniphila en_US
dc.subject Desulfovibrio spp en_US
dc.title A preliminary study examining the binding capacity of akkermansia muciniphila and desulfovibrio spp., to colonic mucin in health and ulcerative colitis en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1007/s11845-015-1285-6
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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