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Evaluation of a novel vascular graft with a distal bifurcation designed to reduce the development of intimal hyperplasia. Experimental study in a porcine aorta model

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dc.contributor.author Vlachovsky, Robert
dc.contributor.author Staffa, Robert
dc.contributor.author Dvorak, Martin
dc.contributor.author Vlasin, Michal
dc.contributor.author Hermanova, Marketa
dc.contributor.author O'Brien, Thomas
dc.contributor.author McGloughlin, Timothy M.
dc.date.accessioned 2016-03-30T09:24:01Z
dc.date.available 2016-03-30T09:24:01Z
dc.date.issued 2014
dc.identifier.citation Vlachovsky, R,Staffa, R,Dvorak, M,Vlasin, M,Hermanova, M,O'Brien, T,McGloughlin, T (2014) 'Evaluation of a novel vascular graft with a distal bifurcation designed to reduce the development of intimal hyperplasia. Experimental study in a porcine aorta model'. Biomedical Papers-Olomouc, 158 :562-568. en_US
dc.identifier.uri http://hdl.handle.net/10344/4988
dc.description peer-reviewed en_US
dc.description.abstract Objective. Abnormal haemodynamics is commonly agreed to be a major contributor to the development of distal anastomotic intimal hyperplasia. A new vascular graft design proposed by computational studies was used to demonstrate its surgical feasibility and to compare it with the conventional graft in a porcine model.Method. The device was used in 12 eight-month-old pigs, six received the new graft and six had a conventional graft. The proximal graft end was implanted into the aorta, the distal graft end was implanted into the iliac artery. The host artery was ligated in order to simulate occlusion. At 20 weeks after surgery the pigs were killed and the device was excised for histological and morphometric analysis.Results. In five experimental grafts the reconstruction was occluded due to thrombosis; only one prosthesis was patent showing a minimum of neointimal hyperplasia. In the control group too only three of the six grafts were patent. A histological analysis revealed, as the cause of occlusion, fibrous tissue overgrowth corresponding in structure to neointimal hyperplasia. Differences in the number of obliterations and in occlusion rates between the profiles of the two groups were evaluated using the median test (P en_US
dc.language.iso eng en_US
dc.publisher Palacky University Olomouc, Faculty of Medicine and Dentistry en_US
dc.relation.uri http://biomed.papers.upol.cz/archive.php
dc.subject animal model en_US
dc.subject anastomosis en_US
dc.subject graft design en_US
dc.subject distal bifurcation en_US
dc.subject intimal hyperplasia en_US
dc.subject experimental study en_US
dc.subject pig en_US
dc.title Evaluation of a novel vascular graft with a distal bifurcation designed to reduce the development of intimal hyperplasia. Experimental study in a porcine aorta model en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2016-03-30T09:11:14Z
dc.description.version PUBLISHED
dc.identifier.doi 10.5507/bp.2013.021
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1577249
dc.internal.copyrightchecked Yes
dc.description.status peer-reviewed


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