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Cervical dystonia: a disorder of the midbrain network for covert attentional orienting.

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Show simple item record Hutchinson, Michael Isa, Tadashi Molloy, Anna Kimmich, Okka Williams, Laura Molloy, Fiona Moore, Helena Healy, Daniel G. Lynch, Tim Walsh, Cathal Dominic Butler, John Reilly, Richard B. Walsh, Richard O'Riordan, Seán 2016-02-29T14:45:03Z 2016-02-29T14:45:03Z 2014
dc.description peer-reviewed en_US
dc.description.abstract While the pathogenesis of cervical dystonia remains unknown, recent animal and clinical experimental studies have indicated its probable mechanisms. Abnormal temporal discrimination is a mediational endophenotype of cervical dystonia and informs new concepts of disease pathogenesis. Our hypothesis is that both abnormal temporal discrimination and cervical dystonia are due to a disorder of the midbrain network for covert attentional orienting caused by reduced gamma-aminobutyric acid (GABA) inhibition, resulting, in turn, from as yet undetermined, genetic mutations. Such disinhibition is (a) subclinically manifested by abnormal temporal discrimination due to prolonged duration firing of the visual sensory neurons in the superficial laminae of the superior colliculus and (b) clinically manifested by cervical dystonia due to disinhibited burst activity of the cephalomotor neurons of the intermediate and deep laminae of the superior colliculus. Abnormal temporal discrimination in unaffected first-degree relatives of patients with cervical dystonia represents a subclinical manifestation of defective GABA activity both within the superior colliculus and from the substantia nigra pars reticulata. A number of experiments are required to prove or disprove this hypothesis. en_US
dc.language.iso eng en_US
dc.publisher Frontiers Media en_US
dc.relation.ispartofseries Frontiers in Neurology;5: 54
dc.rights This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission en_US
dc.subject temporal en_US
dc.subject temporal discrimination en_US
dc.subject covert attention en_US
dc.subject GABA en_US
dc.subject superior colliculus en_US
dc.title Cervical dystonia: a disorder of the midbrain network for covert attentional orienting. en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US 2016-02-29T14:33:22Z
dc.description.version PUBLISHED
dc.contributor.sponsor HRB en_US
dc.relation.projectid CSA-2012/5 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1596365
dc.internal.copyrightchecked Yes
dc.description.status peer-reviewed

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