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Earlier treatment of NMDAR antibody encephalitis in children results in a better outcome.

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dc.contributor.author Bryne, Susan
dc.contributor.author Walsh, Cathal Dominic
dc.contributor.author Harcohen, Yael
dc.contributor.author Muscal, Eyal
dc.contributor.author Jankovic, Joseph
dc.contributor.author Stocco, Amber
dc.contributor.author Dale, Russell C
dc.contributor.author Vincent, Angela
dc.contributor.author Lim, Ming
dc.contributor.author King, Martin
dc.date.accessioned 2016-02-29T11:43:28Z
dc.date.available 2016-02-29T11:43:28Z
dc.date.issued 2015
dc.identifier.citation Byrne S, Walsh C, Hacohen Y, Muscal E, Jankovic J, Stocco A, Dale RC, Vincent A, Lim M, King M (2015) 'Earlier treatment of NMDAR antibody encephalitis in children results in a better outcome'. Neurology(R) neuroimmunology & neuroinflammation, 2 (4). en_US
dc.identifier.uri http://hdl.handle.net/10344/4921
dc.description peer-reviewed en_US
dc.description.abstract The natural history of NMDA receptor (NMDAR) antibody encephalitis in adults and children is altered by treatment with immunosuppressive therapy or tumor removal.1 In adult cohorts, early initiation of immunotherapy appears to be beneficial.1,2 In the largest series to date, Titulaer et al.1 demonstrated that earlier treatment was associated with a modified Rankin Scale (mRS) score of 2 or less in a cohort of 501 adults and children (univariate analysis p5 0.009, multivariable analysis p, 0.0001).Multivariable analysis on 177 children within the cohort showed that earlier treatment was associated with an mRS score of 2 or less, although this did not reach statistical significance (p 5 0.067).1 An mRS score of 2 indicates slight disability and that the patient is unable to carry out all previous activities. en_US
dc.language.iso eng en_US
dc.publisher American Academy of Neurology en_US
dc.relation.ispartofseries Neurology (R) Neuroimmunology & Neuroinflammation;2 (4), e130
dc.relation.uri http://dx.doi.org/ 10.1212/NXI.0000000000000130
dc.subject NMDAR antibody encephalitis en_US
dc.subject treatment en_US
dc.subject children en_US
dc.title Earlier treatment of NMDAR antibody encephalitis in children results in a better outcome. en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2016-02-29T11:29:22Z
dc.description.version PUBLISHED
dc.identifier.doi 10.1212/NXI.0000000000000130
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1596226
dc.internal.copyrightchecked Yes
dc.description.status peer-reviewed


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