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Age-related sexual dimorphism in temporal discrimination and in adult-onset dystonia suggests GABAergic mechanisms

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dc.contributor.author Butler, John S.
dc.contributor.author Beiser, Ines M.
dc.contributor.author Williams, Laura
dc.contributor.author McGovern, Eavan
dc.contributor.author Molloy, Fiona
dc.contributor.author Lynch, Tim
dc.contributor.author Healy, Daniel G.
dc.contributor.author Moore, Helena
dc.contributor.author Walsh, Richard
dc.contributor.author Reilly, Richard B.
dc.contributor.author O'Riordan, Seán
dc.contributor.author Walsh, Cathal Dominic
dc.contributor.author Hutchinson, Michael
dc.date.accessioned 2016-02-26T11:32:46Z
dc.date.available 2016-02-26T11:32:46Z
dc.date.issued 2015
dc.identifier.uri http://hdl.handle.net/10344/4915
dc.description peer-reviewed en_US
dc.description.abstract Background: Adult-onset isolated focal dystonia (AOIFD) presenting in early adult life is more frequent in men, whereas in middle age it is female predominant. Temporal discrimination, an endophenotype of adult-onset idiopathic isolated focal dystonia, shows evidence of sexual dimorphism in healthy participants.Objectives: We assessed the distinctive features of age-related sexual dimorphism of (i) sex ratios in dystonia phenotypes and (ii) sexual dimorphism in temporal discrimination in unaffected relatives of cervical dystonia patients.Methods: We performed (i) a meta-regression analysis of the proportion of men in published cohorts of phenotypes of adult-onset dystonia in relation to their mean age of onset and (ii) an analysis of temporal discrimination thresholds in 220 unaffected first-degree relatives (125 women) of cervical dystonia patients.Results: In 53 studies of dystonia phenotypes, the proportion of men showed a highly significant negative association with mean age of onset (p en_US
dc.language.iso eng en_US
dc.publisher Frontiers Media en_US
dc.relation.ispartofseries Frontiers in Neurology;6 Article 258
dc.rights This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission. en_US
dc.subject adult-onset isolated focal dystonia en_US
dc.subject sex ratio en_US
dc.subject temporal discrimination en_US
dc.subject sexual dimorphism en_US
dc.subject penetrance en_US
dc.title Age-related sexual dimorphism in temporal discrimination and in adult-onset dystonia suggests GABAergic mechanisms en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2016-02-26T11:21:50Z
dc.description.version PUBLISHED
dc.identifier.doi 10.3389/fneur.2015.00258
dc.contributor.sponsor HRB en_US
dc.relation.projectid CSA-2012-5 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1629108
dc.internal.copyrightchecked Yes
dc.description.status peer-reviewed


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