dc.contributor.author | Butler, John S. | |
dc.contributor.author | Beiser, Ines M. | |
dc.contributor.author | Williams, Laura | |
dc.contributor.author | McGovern, Eavan | |
dc.contributor.author | Molloy, Fiona | |
dc.contributor.author | Lynch, Tim | |
dc.contributor.author | Healy, Daniel G. | |
dc.contributor.author | Moore, Helena | |
dc.contributor.author | Walsh, Richard | |
dc.contributor.author | Reilly, Richard B. | |
dc.contributor.author | O'Riordan, Seán | |
dc.contributor.author | Walsh, Cathal Dominic | |
dc.contributor.author | Hutchinson, Michael | |
dc.date.accessioned | 2016-02-26T11:32:46Z | |
dc.date.available | 2016-02-26T11:32:46Z | |
dc.date.issued | 2015 | |
dc.identifier.uri | http://hdl.handle.net/10344/4915 | |
dc.description | peer-reviewed | en_US |
dc.description.abstract | Background: Adult-onset isolated focal dystonia (AOIFD) presenting in early adult life is more frequent in men, whereas in middle age it is female predominant. Temporal discrimination, an endophenotype of adult-onset idiopathic isolated focal dystonia, shows evidence of sexual dimorphism in healthy participants.Objectives: We assessed the distinctive features of age-related sexual dimorphism of (i) sex ratios in dystonia phenotypes and (ii) sexual dimorphism in temporal discrimination in unaffected relatives of cervical dystonia patients.Methods: We performed (i) a meta-regression analysis of the proportion of men in published cohorts of phenotypes of adult-onset dystonia in relation to their mean age of onset and (ii) an analysis of temporal discrimination thresholds in 220 unaffected first-degree relatives (125 women) of cervical dystonia patients.Results: In 53 studies of dystonia phenotypes, the proportion of men showed a highly significant negative association with mean age of onset (p | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Frontiers Media | en_US |
dc.relation.ispartofseries | Frontiers in Neurology;6 Article 258 | |
dc.rights | This Document is Protected by copyright and was first published by Frontiers. All rights reserved. it is reproduced with permission. | en_US |
dc.subject | adult-onset isolated focal dystonia | en_US |
dc.subject | sex ratio | en_US |
dc.subject | temporal discrimination | en_US |
dc.subject | sexual dimorphism | en_US |
dc.subject | penetrance | en_US |
dc.title | Age-related sexual dimorphism in temporal discrimination and in adult-onset dystonia suggests GABAergic mechanisms | en_US |
dc.type | info:eu-repo/semantics/article | en_US |
dc.type.supercollection | all_ul_research | en_US |
dc.type.supercollection | ul_published_reviewed | en_US |
dc.date.updated | 2016-02-26T11:21:50Z | |
dc.description.version | PUBLISHED | |
dc.identifier.doi | 10.3389/fneur.2015.00258 | |
dc.contributor.sponsor | HRB | en_US |
dc.relation.projectid | CSA-2012-5 | en_US |
dc.rights.accessrights | info:eu-repo/semantics/openAccess | en_US |
dc.internal.rssid | 1629108 | |
dc.internal.copyrightchecked | Yes | |
dc.description.status | peer-reviewed |