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Adherence to antiretrovirals among US women during and after pregnancy

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Show simple item record Bardeguez, Arlene D. Lindsey, Jane C. Shannon, Maureen Tuomala, Ruth E. Cohn, Susan E. Smith, Elizabeth Stek, Alice Buschur, Shelly Cotter, Amanda Bettica, Linda Read, Jennifer S. 2016-02-18T14:52:33Z 2016-02-18T14:52:33Z 2009
dc.description peer-reviewed en_US
dc.description.abstract Background—Antiretrovirals (ARVs) are recommended for maternal health and to reduce HIV-1 mother-to-child transmission, but suboptimal adherence can counteract its benefits. Objectives—To describe antepartum and postpartum adherence to ARV regimens and factors associated with adherence. Methods—We assessed adherence rates among subjects enrolled in Pediatric AIDS Clinical Trials Group Protocol 1025 from August 2002 to July 2005 on tablet formulations with at least one self-report adherence assessment. Perfectly adherent subjects reported no missed doses 4 days before their study visit. Generalized estimating equations were used to compare antepartum with postpartum adherence rates and to identify factors associated with perfect adherence. Results—Of 519 eligible subjects, 334/445 (75%) reported perfect adherence during pregnancy. This rate significantly decreased 6, 24, and 48 weeks postpartum [185/284 (65%), 76/118 (64%), and 42/64 (66%), respectively (P < 0.01)]. Pregnant subjects with perfect adherence had lower viral loads. The odds of perfect adherence were significantly higher for women who initiated ARVs during pregnancy (P < 0.01), did not have AIDS (P = 0.02), never missed prenatal vitamins (P < 0.01), never used marijuana (P = 0.05), or felt happy all or most of the time (P < 0.01). Conclusions—Perfect adherence to ARVs was better antepartum, but overall rates were low. Interventions to improve adherence during pregnancy are needed. en_US
dc.language.iso eng en_US
dc.publisher Lippincott Williams & Wilkins en_US
dc.relation.ispartofseries Journal of Acquired Immune Deficiency Syndromes;48 (4), pp. 408-417
dc.rights This is the author version of " Adherence to Antiretrovirals Among US Women During and After Pregnancy" the final published version is available at en_US
dc.subject pregnancy en_US
dc.subject adherence en_US
dc.subject HIV-1 infection en_US
dc.subject substance use en_US
dc.subject depression en_US
dc.subject viral suppression en_US
dc.title Adherence to antiretrovirals among US women during and after pregnancy en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US

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