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Browsing Theses: Faculty of Science & Engineering by Author "Dalton, Tara"

Now showing items 1-8 of 8

Characterisation of the fundamental function(s) of bovine serum albumin in the culture of NS0 cells

McNamara, Liam (University of Limerick, 2016)

The large-scale production of therapeutic monoclonal antibodies (mAbs) is commonly carried out using NS0 cells, which are a cholesterol deficient mouse myeloma cell line. The non-ionic surfactant Pluronic F-68 is routinely ...
Continuous flow digital PCR for absolute quantification of nucleic acids

Dalton, Mark A. (University of Limerick, 2012)

Digital polymerase chain reaction (PCR) has emerged as an extremely powerful technique for quantification of nucleic acids. Digital PCR offers superior quantification accuracy, precision and sensitivity compared to ...
Development of a laminar shear apparatus for characterising the shear-mitigating effect(s) of bovine serum albumin in mammalian cell suspension culture

Collins, Michael (University of Limerick, 2019)

The stirred tank bioreactor is one of the most widely-utilised technologies in the biopharmaceutical industry for large-scale mammalian cell culture resulting in the production of therapeutic monoclonal antibodies. In these ...
Direct amplification of nucleic acids from cells

Fleming, Paul (University of Limerick, 2011)

All biological conditions, whether pathological or a cellular response to extra cellular signals, are reflected in changes in gene expression. Gene expression profiling is therefore a valuable tool in many areas, including ...
On slip flow and interfacial phenomena within superhydrophobic microchannels

O'Keeffe, Niall (University of Limerick, 2012)

The unique wetting properties of superhydrophobic (SH) surfaces have attracted a considerable interest in recent years. Their ability to repel liquids produces some remarkable characteristics such as spherical droplet ...
On the development of a microfluidic instrument for preclinical cell analysis

Keays, Catherine Marie (University of Limerick, 2017)

The evolution of a new drug is initiated by testing new compounds in a preclinical laboratory setting. The methods for discovering new drugs involve scrutiny of a drug’s efficacy on a cell model of a disease. Current ...
On the utilisation of Taylor flows for automated cell to signal

McCarthy, Conor T. (University of Limerick, 2015)

Microfluidics has enormous potential as a tool for developing new technology and reducing cost. In this thesis, Taylor flows are utilized to develop an automated system capable of loading, transporting, processing and ...
The utilisation of microfluidic qPCR technology for the identification of novel cancer biomarkers

Hayes, Christopher J. (University of Limerick, 2017)

Cancer is a major cause of death worldwide causing 1 in 6 deaths globally with approximately 14 million new cases and 8.8 million cancer related deaths in 2015. This figure is expected to increase to 21.7 million cases and ...

Browsing Theses: Faculty of Science & Engineering by Author "Dalton, Tara"

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Browsing Theses: Faculty of Science & Engineering by Author "Dalton, Tara"

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