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Potential for alcohol and drug interactions in older adults: evidence from the Irish longitudinal study on ageing

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dc.contributor.author Cousins, Gráinne
dc.contributor.author Galvin, Rose
dc.contributor.author Flood, Michelle
dc.contributor.author Kennedy, Mary-Claire
dc.contributor.author Motterlini, Nicola
dc.contributor.author Henman, Martin C
dc.contributor.author Kenny, Rose Anne
dc.contributor.author Fahey, Tom
dc.date.accessioned 2015-11-30T15:54:36Z
dc.date.available 2015-11-30T15:54:36Z
dc.date.issued 2014
dc.identifier.uri http://hdl.handle.net/10344/4759
dc.description peer-reviewed en_US
dc.description.abstract Background: Older adults are susceptible to adverse effects from the concomitant use of prescription medications and alcohol. This study estimates the prevalence of exposure to alcohol interactive (AI) medications and concomitant alcohol use by therapeutic class in a large, nationally representative sample of older adults. Methods: Cross-sectional analysis of a population based sample of older Irish adults aged ≥60 years using data from The Irish Longitudinal Study on Ageing (TILDA) (N = 3,815). AI medications were identified using Stockley’s Drug Interactions, the British National Formulary and the Irish Medicines Formulary. An in-home inventory of medications was used to characterise AI drug exposure by therapeutic class. Self-reported alcohol use was classified as non-drinker, light/moderate and heavy drinking. Comorbidities known to be exacerbated by alcohol were also recorded (diabetes mellitus, hypertension, peptic ulcer disease, liver disease, depression, gout or breast cancer), as well as sociodemographic and health factors. Results: Seventy-two per cent of participants were exposed to AI medications, with greatest exposure to cardiovascular and CNS agents. Overall, 60% of participants exposed to AI medications reported concomitant alcohol use, compared with 69.5% of non-AI exposed people (p < 0.001). Almost 28% of those reporting anti-histamine use were identified as heavy drinkers. Similarly almost one in five, combined heavy drinking with anti-coagulants/anti-platelets and cardiovascular agents, with 16% combining heavy drinking with CNS agents. Multinomial logistic regression showed that being male, younger, urban dwelling, with higher levels of education and a history of smoking, were associated with an increased risk for concomitant exposure to alcohol consumption (both light/moderate and heavier) and AI medications. Current smokers and people with increasing co-morbidities were also at greatest risk for heavy drinking in combination with AI medications. Conclusions: The concurrent use of alcohol with AI medications, or with conditions known to be exacerbated by alcohol, is common among older Irish adults. Prescribers should be aware of potential interactions, and screen patients for alcohol use and provide warnings to minimize patient risk. en_US
dc.language.iso eng en_US
dc.publisher BioMed Central en_US
dc.relation.ispartofseries BMC Geriatrics;14:57
dc.subject drug interactions en_US
dc.subject alcohol interactive medication en_US
dc.subject alcohol drinking epidemiology en_US
dc.subject aged en_US
dc.title Potential for alcohol and drug interactions in older adults: evidence from the Irish longitudinal study on ageing en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1186/1471-2318-14-57
dc.contributor.sponsor HRB en_US
dc.relation.projectid HRC/2007/1 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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