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Browsing Health Research Institute (HRI) by Author "Sauer, Ann Katrin"

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Altered intestinal morphology and microbiota composition in the autism spectrum disorders associated SHANK3 mouse model

Sauer, Ann Katrin; Bockmann, Juergen; Steinestel, Konrad; Boeckers, Tobias M.; Grabrucker, Andreas M. (MDPI, 2019)

Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders characterized by deficits in social interaction and communication, and repetitive behaviors. In addition, co-morbidities such as gastro-intestinal ...
Brain lateralization in mice is associated with zinc signaling and altered in prenatal zinc deficient mice that display features of autism spectrum disorder

Grabrucker, Stefanie; Haderspeck, Jasmin C.; Sauer, Ann Katrin; Kittelberger, Nadine; Asoglu, Harun; Abaei, Alireza; Rasche, Volker; Schon, Michael; Boeckers, Tobias M.; Grabrucker, Andreas M. (Frontiers Media, 2018)

A number of studies have reported changes in the hemispheric dominance in autism spectrum disorder (ASD) patients on functional, biochemical, and morphological level. Since asymmetry of the brain is also found in many ...
Nanomedicine against Aβ aggregation by β–sheet breaker peptide delivery:In vitro evidence

Pederzoli, Francesca; Ruozi, Barbara; Duskey, Jason T.; Hagmeyer, Simone; Sauer, Ann Katrin; Grabrucker, Stefanie; Coelho, Romina; Oddone, Natalia; Ottonelli, Ilaria; Daini, Eleonora; Zoli, Michele; Vandelli, Maria Angela; Tosi, Giovanni; Grabrucker, Andreas M. (MDPI, 2019)

The accumulation of amyloid β (Aβ) triggers a cascade of toxic events in Alzheimer’s disease (AD). The KLVFF peptide can interfere with Aβ aggregation. However, the peptide suffers from poor bioavailability and the inability ...
Prospects of zinc supplementation in autism spectrum disorders and shankopathies Such as Phelan McDermid Syndrome.

Hagmeyer, Simone; Sauer, Ann Katrin; Grabrucker, Andreas M. (Frontiers Media, 2018)

The loss of one copy of SHANK3 (SH3 and multiple ankyrin repeat domains 3) in humans highly contributes to Phelan McDermid syndrome (PMDS). In addition, SHANK3 was identified as a major autism candidate gene. Interestingly, ...
Reduced plaque size and inflammation in the APP23 mouse model for Alzheimer’s disease after chronic application of polymeric nanoparticles for CNS targeted zinc delivery

Vilella, Antonietta; Belletti, Daniela; Sauer, Ann Katrin; Hagmeyer, Simone; Sarowar, Tasnuva; Masoni, Martina; Stasiak, Natalia; Mulvihill, John J.E.; Ruozi, Barbara; Forni, Flavio; Vandelli, Maria Angela; Tosi, Giovanni; Zoli, Michele; Grabrucker, Andreas M. (Elsevier, 2017)

A local dyshomeostasis of zinc ions in the vicinity of amyloid aggregates has been proposed in Alzheimer’s disease (AD) due to the sequestration of zinc in senile plaques. While an increase in zinc levels may promote the ...
Zinc deficiency during pregnancy leads to altered microbiome and elevated inflammatory markers in mice

Sauer, Ann Katrin; Grabrucker, Andreas M. (Frontiers Media, 2019)

Zinc is an essential trace metal for bacteria of the intestinal flora. Approximately 20% of dietary zinc – intake is used by intestinal bacteria. The microbiome has recently been described as an important factor for ...

Browsing Health Research Institute (HRI) by Author "Sauer, Ann Katrin"

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