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Browsing Health Research Institute (HRI) by Title

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  • Pederzoli, Francesca; Ruozi, Barbara; Duskey, Jason T.; Hagmeyer, Simone; Sauer, Ann Katrin; Grabrucker, Stefanie; Coelho, Romina; Oddone, Natalia; Ottonelli, Ilaria; Daini, Eleonora; Zoli, Michele; Vandelli, Maria Angela; Tosi, Giovanni; Grabrucker, Andreas M. (MDPI, 2019)
    The accumulation of amyloid β (Aβ) triggers a cascade of toxic events in Alzheimer’s disease (AD). The KLVFF peptide can interfere with Aβ aggregation. However, the peptide suffers from poor bioavailability and the inability ...
  • Fitzgerald, Catherine; Linnane, Barry; George, Sherly; Ni Chronin, Muireann; Mullane, David; Herzig, Mary; Greally, Peter; Elnazir, Basil; Healy, Fiona; McNally, Paul; Javadpour, Sheila; Cox, Des; Fitzpatrick, Patricia (Wiley and Sons Ltd, 2020)
    The introduction of NBS in Ireland in July 2011, provided a unique opportunity to investigate clinical outcomes using a comparative historical cohort study. Clinical cohort: children clinically diagnosed with CF born 1 ...
  • Lawlor, Brian; Segurado, Ricardo; Kennelly, Sean; Olde Rikkert, Marcel G. M.; Howard, Robert; Pasquier, Florence; Borjesson-Hanson, Anne; Tsolaki, Magda; Lucca, Ugo; William Molloy, D; Coen, Robert; Riepe, Matthias W.; Kálmán, János; Kenny, Rose Anne; Cregg, Fiona; O'Dwyer, Sarah; Walsh, Cathal Dominic; Adams, Jessica; Banzi, Rita; Breuilh, Laetitia; Daly, Leslie; Hendrix, Suzanne; Aisen, Paul; Gaynor, Siobhan; Sheikhi, Ali; Taekema, Diana G.; Verhey, Frans R.; Nemni, Raffaello; Nobili, Flavio; Franceschi, Massimo; Frisoni, Giovanni; Zanetti, Orazio; Konsta, Anastasia; Anastasios, Orologas; Nenopoulou, Styliani; Tsolaki-Tagaraki, Fani; Pakaski, Magdolna; Dereeper, Olivier; de la Sayette, Vincent; Sénéchal, Olivier; Lavenu, Isabelle; Devendeville, Agnés; Calais, Gauthier; Crawford, Fiona; Mullan, Michael (Public Library of Science, 2018)
    Background This study reports the findings of the first large-scale Phase III investigator-driven clinical trial to slow the rate of cognitive decline in Alzheimer disease with a dihydropyridine (DHP) calcium channel ...
  • Jennings, Mark; Guilfoyle, Aoife; Green, James; Cleary, Yvonne; Gowran, Rosemary Joan (MDPI, 2020)
    Background: Children with spina bifida and/or hydrocephalus (SB&/H) often experience difficulties with activities of daily living (ADLs) due to impaired executive functioning, increasing sedentary behaviours. The HeyJoy ...
  • Bashar, Khalid; Healy, Donagh A.; Elsheikh, Sawsan; Browne, Leonard D.; Walsh, Michael T.; Clarke-Moloney, Mary; Burke, Paul E.; Kavanagh, Eamon G.; Walsh, Stewart R. (Public Library of Science, 2015)
    A brachiobasilic arteriovenous fistula (BB-AVF) can provide access for haemodialysis in patients who are not eligible for a more superficial fistula. However, it is unclear whether one or two-stage BB-AVF is the best option ...
  • MacFarlane, Anne E. (Taylor and Francis, 2020)
    The World Health Organisation Alma-Ata Declaration on Primary Healthcare, and the more recent Astana Declaration from the Global Conference on Primary Healthcare, emphasise the involvement of individuals and communities ...
  • Murphy, Sylvia M.; Kiely, Maeve; Jakeman, Philip M.; Kiely, Patrick A.; Carson, Brian P. (Portland Press, 2016)
    The importance of growth and maintenance of skeletal muscle is vital for long term health and quality of life. Appropriate nutrition with specific bioactivities relevant to the functionalities of tissues such as skeletal ...
  • Konstantinos, Siontis C.; Zhang, Xiaosong; Eckard, Ashley; Bhave, Nicole; Schaubel, Douglas E.; He, Kevin; Tilea, Anca; Stack, Austin G.; Balkrishnan, Rajesh; Yao, Xiaoxi; Noseworthy, Peter A.; Shah, Nilay D.; Saran, Rajiv; Nallamothu, Brahmajee K. (Lippincott, Williams & Wilkins, 2018)
    Background: Patients with end-stage kidney disease (ESKD) on dialysis were excluded from clinical trials of direct oral anticoagulants for atrial fibrillation (AF). Recent data have raised concerns regarding the safety ...
  • McMahon, Grace; Creaven, Ann-Marie; Gallagher, Stephen (Wiley and Sons Ltd, 2019)
    To understand the influence of social relationships on cardiovascular responses to stress, the present study investigated perceived affectionate support as a mediating variable explaining the association between specific ...
  • Bengoechea, Enrique García; Wilson, Philip M.; Dunn, Steven (SAGE Publications, 2020)
    Despite calls in the literature, little is known about how dimensions of a social and task nature relate to each other in school and out-of-school learning environments. This study explored whether interpersonal and task ...
  • Thomas, Valentina; Cotter, Maura B.; Tosetto, Miriam; Khaw, Yi Ling; Geraghty, Robert; Winter, Desmond C; Ryan, Elizabeth J.; Sheahan, Kieran; Furney, Simon J. (Nature Research, 2020)
    Synchronous colorectal cancers (syCRCs) are two or more primary tumours identified simultaneously in a patient. Previous studies report high inter-tumour heterogeneity between syCRCs, suggesting independent origin and ...
  • Manning, Molly; MacFarlane, Anne E.; HIckey, Anne; Franklin, Sue (Public Library of Science, 2019)
    Background There is increased focus on supporting people with chronic conditions to live well via person- centred, integrated care. There is a growing body of qualitative literature examining the insider perspectives ...
  • Vancampfort, Davy; Stubbs, Brendon; Smith, Lee; Hallgren, Mats; Firth, Joseph; Herring, Matthew P.; Probst, Michel; Koyanagi, Ai (Elsevier, 2018)
    Objective: Although physical activity (PA) is associated with a reduction of a wide range of sleep problems, it remains uncertain whether complying with the international guidelines of 150 min of moderate to vigorous PA ...
  • Hammar, Åsa; Semkovska, Maria; Borgen, Ida M. H.; Myklebost, Sunniva; Ronold, Eivind H.; Sveen, Thea; Ueland, Torill; Porter, Richard; Johnson, Sheri L. (Taylor and Francis, 2020)
    Major depressive disorder (MDD) is associated with working memory (WM) impairments. These deficits often persist following remission and are associated with rumination, a recognized risk factor for depression relapse. The ...
  • Glynn, Liam G.; Mustafa, Alaa; Casey, Monica; Krawczyk, Janusz; Blom, Jeanet; Galvin, Rose; Hannigan, Ailish; Dunne, Colum P.; Murphy, Andrew W.; Mallen, Christian (BioMed Central, 2018)
    Background: Platelet-rich plasma (PRP) is a concentrate of autologous blood growth factors which has been shown to provide some symptomatic relief in early osteoarthritis (OA) of the knee. The objective of this study was ...
  • O'Keeffe, M; Kelly, M; O'Herlihy, E; O'Toole, Paul W.; Kearney, P.M.; Timmons, Suzanne; O'Shea, E; Stanton, C; Hickson, M; Rolland, Y; Rosse, Sulmont; Issanchou, S; Maitre, I; Stelmach-Mardas, M; Nagel, G; Flechtner-Mors, M; Wolters, M; Hebestreit, A; De Groot, L.C.P.G.M; van de Rest, O; Teh, Ruth; Peyron, M.A; Dardevet, D; Papet, I; Schindler, K; Streicher, M; Torbahn, G; Kiesswetter, E; Visser, M; Volkert, Dorothee; O'Connor, E.M; *on behalf of the MaNuEL consortium (Elsevier, 2019)
    Background & aims: Malnutrition in older adults results in significant personal, social, and economic burden. To combat this complex, multifactorial issue, evidence-based knowledge is needed on the modifiable determinants ...
  • Verdu-Rotellar, José María; Vaillant-Roussel, Helene; Abellana, Rosa; Jevsek, Lea Gril; Assenova, Radost; Lazic, Djurdjica Kasuba; Torsza, Peter; Glynn, Liam G.; Lingner, Heidrun; Demurtas, Jacopo; Borgström, Beata; Gibot-Boeuf, Sylvaine; Muñoz, Miguel Angel (Taylor & Francis, 2020)
    Objective: To evaluate the precipitating factors for heart failure decompensation in primary care and associations with short-term prognosis. Design Prospective cohort study with a 30-d follow-up from an index consultation. ...
  • Healy, Donagh A.; Clarke-Moloney, Mary; Gaughan, Brendan; O'Daly, Siobhan; Hausenloy, Derek; Sharif, Faisal; Newell, John; O'Donnell, Martin; Grace, Pierce A.; Forbes, John F.; Cullen, Walter; Kavanagh, Eamon G.; Burke, Paul E.; Cross, Simon; Dowdall, Joseph; McMonagle, Morgan; Fulton, Greg J.; Manning, Brian J; Kheirelseid, Elrasheid A. H.; Leahy, Austin; Moneley, Daragh; Naughton, Peter; Boyle, Emily; McHugh, Seamus; Madhaven, Prakash; O'Neill, Sean; Martin, Zenia; Courtney, Donal; Tubassam, Muhammed; Sultan, Sherif; McCartan, Damian; Medani, Mekki; Walsh, Stewart R. (BioMed Central, 2015)
    Background: Patients undergoing vascular surgery procedures constitute a 'high-risk' group. Fatal and disabling perioperative complications are common. Complications arise via multiple aetiological pathways. This mechanistic ...
  • Cunnane, Connor V.; Cunnane, Eoghan M.; Moran, Daniel T.; Walsh, Michael T. (Wiley and Sons Ltd, 2019)
    Areas of disturbed shear that develop following arteriovenous fistula (AVF) creation are believed to trigger the onset of intimal hyperplasia (IH), leading to AVF dysfunction. The presence of helical flow can suppress the ...
  • McCormack, Hannah M.; MacIntyre, Tadhg E.; O'Shea, Deirdre; Herring, Matthew P.; Campbell, Mark J. (Frontiers Media, 2018)
    Purpose: Burnout has been shown to develop due to chronic stress or distress, which has negative implications for both physical and mental health and well-being. Burnout research originated in the “caring-professions.” ...

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