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Browsing Health Research Institute (HRI) by Title

Now showing items 128-147 of 334

The global nephrology workforce: emerging threats and potential solutions!

Sharif, Muhammad U.; Elsayed, Mohamed E.; Stack, Austin G. (Oxford University Press, 2016)

Amidst the rising tide of chronic kidney disease (CKD) burden, the global nephrology workforce has failed to expand in order to meet the growing healthcare needs of this vulnerable patient population. In truth, this ...
Gout and the risk of advanced chronic kidney disease in the UK health system: a national cohort study

Stack, Austin G.; Johnson, Michelle Elizabeth; Blak, Betina; Klein, Alyssa; Carpenter, Lewis; Morlock, Robert; Maguire, Andrew R.; Parsons, Victoria L. (BMJ, 2019)

Objective Evaluate the association between gout and riskof advanced chronic kidney disease (CKD).Design Retrospective matched cohort study.Setting UK Clinical Practice Research Datalink.Participants The analysis included ...
Guiding therapy by coronary CT angiography improves outcomes in patients with stable chest pain

Adamson, Philip D.; Williams, Michelle C.; Dweck, Marc R.; Mills, Nicholas L.; Boon, Nicholas A.; Daghem, Marwa; Bing, Rong; Moss, Alastair J.; Mangion, Kenneth; Flather, Marcus; Forbes, John F.; Hunter, Amanada; Norrie, John; Shah, Anoop S.V.; Timmis, Adam D.; van Beek, Edwin J.R.; Ahmandi, Amir A.; Leipsic, Jonathon; Narula, Jagat; Newby, David E.; Roditi, Giles; McAllister, David A.; Berry, Colin (Elsevier, 2019)

BACKGROUND Within the SCOT-HEART (Scottish COmputed Tomography of the HEART Trial) trial of patients with stable chest pain, the use of coronary computed tomography angiography (CTA) reduced the rate of death from ...
Health-ID: A blockchain-based decentralized identity management for remote healthcare

Javed, Ibrahim Tariq; Alharbi, Fares; Bellaj, Badr; Margaria, Tiziana; Crespi, Noel; Qureshi, Kashif Naseer (MDPI, 2021)

COVID-19 has made eHealth an imperative. The pandemic has been a true catalyst for remote eHealth solutions such as teleHealth. Telehealth facilitates care, diagnoses, and treatment remotely, making them more efficient, ...
Health-seeking behavior of people in indonesia: A narrative review

Widayanti, Anna Wahyuni; Green, James A.; Heydon, Susan; Norris, Pauline (Elsevier, 2020)

This review aims to locate existing studies on health-seeking behavior of people in Indonesia, identify gaps, and highlight important findings. Articles were retrieved from Medline, Scopus, Web of Science, Academic Search ...
Hepatitis C in the era of direct-acting antivirals: real-world costs of untreated chronic hepatitis C; a cross-sectional study

Kieran, Jennifer Ann; Norris, Suzanne; O'Leary, Aisling; Walsh, Cathal Dominic; Merriman, Raphael; Houlihan, D.; McCormick, Aiden; McKiernan, Susan; Bergin, Colm; Barry, Michael (BioMed Central, 2015)

Background: Recent advances in Hepatitis C therapeutics offer the possibility of cure but will be expensive. The cost of treatment may be partially offset by the avoidance of advanced liver disease. We performed a micro-costing ...
High rate of adherence to urate-lowering treatment in patients with gout: who’s to blame?

Perez-Ruiz, Fernando; Perez-Herrero, Nuria; Richette, Pascal; Stack, Austin G. (Springer, 2020)

Introduction: Gout is commonly associated with low adherence rates, thus limiting the effectiveness of treatment. Nevertheless, informed and empowered patients may be more likely to achieve high adherence. We intend ...
High vitamin D levels may downregulate inflammation in patients with Behcet's disease

Adeeb, Fahd; Usman Khan, Maria; Li, Xia; Stack, Austin G.; Devlin, Joseph; Fraser, Alexander D. (Hindawi Publishing Corporation, 2017)

Vitamin D plays a significant role in the immune system modulation and may confer a protective role in autoimmune diseases. We conducted a case-control study to compare 25(OH)D levels in patients with BD who were managed ...
High-Sensitivity cardiac troponin I and the diagnosis of coronary artery disease in patients with suspected angina pectoris

Adamson, Philip D.; Hunter, Amanda; Madsen, Debbie M.; Shah, Anoop S.V.; McAllister, David A.; Pawade, Tania A.; Williams, Michelle C.; Berry, Colin; Boon, Nicholas A.; Flather, Marcus; Forbes, John F.; McLean, Scott; Roditi, Giles; Timmis, Adam D.; van Beek, Edwin J.R.; Dweck, Marc R.; Mickley, Hans; Mills, Nicholas L.; Newby, David E. (American Heart Association, 2018)

Background: We determined whether high-sensitivity cardiac troponin I can improve the estimation of the pretest probability for obstructive coronary artery disease (CAD) in patients with suspected stable angina. Methods ...
A hot-cold cognitive model of depression: Integrating the neuropsychological approach into the cognitive theory framework

Ahern, Elayne; Bockting, Claudi L.H; Semkovska, Maria (PsychOpen, 2019)

Background: In the 50 years following Beck’s cognitive theory, empirical research has consistently supported the role of dysfunctional, ‘hot’ cognition in the onset and maintenance of major depressive disorder. Compromised ...
Household medication safety practices during the COVID-19 pandemic: a descriptive qualitative study protocol

Grimes, Tamasine C.; Garfield, Sara; Kelly, Dervla; Cahill, Joan; Cromie, Sam; Wheeler, Carly; Franklin, Bryony Dean (BMJ Publishing Group, 2020)

Introduction Those who are staying at home and reducing contact with other people during the COVID-19 pandemic are likely to be at greater risk of medicationrelated problems than the general population. This study aims ...
Hybrid nanoparticles as a new technological approach to enhance the delivery of cholesterol into the brain

Belletti, Daniela; Grabrucker, Andreas M.; Pederzoli, Francesca; Menrath, Isabel; Vandelli, Maria Angela; Tosi, Giovanni; Duskey, Jason T.; Forni, Flavio; Ruozi, Barbara (Elsevier, 2018)

Restoration of the Chol homeostasis in the Central Nervous System (CNS) could be beneficial for the treatment of Huntington's Disease (HD), a progressive, fatal, adult-onset, neurodegenerative disorder. Unfortunately, Chol ...
Identification of health-related behavioural clusters and their association with demographic characteristics in Irish university students

Murphy, Joseph J.; MacDonncha, Ciaran; Murphy, Marie H.; Murphy, Niamh M.; Timperio, Anna; Leech, Rebecca M.; Woods, Catherine B. (BMC, 2019)

Background: Students engage in risky health-related behaviours that influence their current and future health status. Health-related behaviours cluster among adults and differently based on sub-populations characteristics ...
Identifying trial recruitment uncertainties using a James Lind alliance priority setting partnership – the priority (prioritising recruitment in randomised trials) study

Healy, Patricia; Galvin, Sandra; Williamson, Paula R.; Treweek, Shaun; Whiting, Caroline; Maeso, Beccy; Bray, Christopher; Brocklehurst, Peter; Clarke-Moloney, Mary; Douiri, Abdel; Gamble, Carrol; Gardner, Heidi R.; Mitchell, Derick; Stewart, Derek; Jordan, Joan; O'Donnell, Martin; Clarke, Mike; Pavitt, Sue H.; Woodford Guegan, Eleanor; Blatch-Jones, Amanda; Smith, Valerie; Reay, Hannah; Devane, Declan (BioMed Central, 2018)

Background: Despite the problem of inadequate recruitment to randomised trials, there is little evidence to guide researchers on decisions about how people are effectively recruited to take part in trials. The PRioRiTy ...
‘If relevant, yes; if not, no’: general practitioner (GP) users and GP perceptions about asking ethnicity questions in Irish general practice: A qualitative analysis using normalization process theory

Roura, Maria; LeMaster, Joseph W.; Hannigan, Ailish; Papyan, Anna; McCarthy, Sharon; Nurse, Diane; Villarroe, Nazmy; MacFarlane, Anne E. (Public Library of Science, 2021)

Context The use of ethnic identifiers in health systems is recommended in several European countries as a means to identify and address heath inequities. There are barriers to implementation that have not been researched. ...
Impact of early assessment and intervention by teams involving health and social care professionals in the emergency department: A systematic review

Cassarino, Marica; Robinson, Katie; Quinn, Rosie; Naddy, Breda; O'Regan, Andrew; Ryan, Damien; Boland, Fiona; Ward, Marie E. (Public Library of Science, 2019)

Dedicated Health and Social Care Professional (HSCP) teams have been proposed for emergency departments (EDs) in an effort to improve patient and process outcomes. This systematic review synthesises the totality of ...
The impact of individual patient data in a network meta-analysis: an investigation into parameter estimation and model selection

Leahy, Joe; O'Leary, Aisling; Afdhal, Nezam; Gray, Emma; Milligan, Scott; Wehmeyer, Malte H.; Walsh, Cathal Dominic (Wiley and Sons Ltd, 2018)

The use of individual patient data (IPD) in network meta-analysis (NMA) is becoming increasingly popular. However, as most studies do not report IPD, most NMAs are performed using aggregate data for at least some, if not ...
Improving outcomes among young adults with type 1 diabetes: the D1 now randomised pilot study protocol

Casey, Bláthín; Byrne, M.; Casey, D.; Gillespie, Paddy; Hobbins, A.; Newell, John; Morrissey, Eimear C.; Dinneen, S.F. (Wiley and Sons Ltd, 2020)

Background Young adults (18‐25 years old) living with type 1 diabetes mellitus often have sub‐optimal glycaemic levels which can increase their risk of long term diabetes complications. Informed by health psychology theory ...
In vitro and In vivo effects of palmaria palmata derived peptides on glucose metabolism

Harnedy-Rothwell, Pádraigín A.; McLaughlin, Chris M.; Le Gouic, Aurélien V.; Mullen, Ciaran; Parthsarathy, Vadivel; Allsopp, Philip J.; McSorley, Emeir M.; FitzGerald, Richard J.; O’Harte, Finbarr P. M. (Springer, 2021)

Three synthetic peptides, ILAP, LLAP and MAGVDHI, derived from a Palmaria palmata protein hydrolysate were assessed for their antidiabetic potential in vitro and in vivo. In addition to inhibiting dipeptidyl peptidase-IV ...
The in vitro inertial positions and viability of cells in suspension under different in vivo flow conditions

Connolly, Sinéad Á.; McGourty, Kieran Denis; Newport, David (Nature Research, 2020)

The influence of Poiseuille flow on cell viability has applications in the areas of cancer metastasis, lab-on-a-chip devices and flow cytometry. Indeed, retaining cell viability is important in the emerging field of cell ...

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