University of Limerick Institutional Repository

Health Research Institute (HRI)

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Health Research Institute (HRI)

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The Health Research Institute (HRI) is a cross faculty institute that brings together researchers in UL and its partner institutions with a focus on convergent and translational health research. The mission of the HRI is to conduct outstanding transformative research in order to improve the health and well-being of individuals, patients, communities and populations. The HRI research activity is structured around the following thematic areas:

  • Technology Enhanced Health Outcomes
  • Lifestyle and Health
  • Health Service Delivery

The activities of the HRI are supported by expertise in biostatistics, health informatics and health economics, and facilitated by the Clinical Research Support Unit (CRSU). The UL/UL Hospitals Clinical Research Unit (CRU) is the first agreed CRSU partnership and is located at University Hospital Limerick (UHL). Our goal is to provide a rich collaborative environment that fosters discovery and innovation in health science that will lead to better health, improved care and a healthier society.

For more information see the HRI website.

Recent Submissions

  • Elsayed, Mohamed E.; Ferguson, John P.; Stack, Austin G. (Dove Medical Press, 2016)
    The association of adult height withmortality has been extensively investigated in the general population, but little is known about this relationship among dialysis patients. We explored the relationship between height ...
  • Lawlor, Brian; Segurado, Ricardo; Kennelly, Sean; Olde Rikkert, Marcel G. M.; Howard, Robert; Pasquier, Florence; Borjesson-Hanson, Anne; Tsolaki, Magda; Lucca, Ugo; William Molloy, D; Coen, Robert; Riepe, Matthias W.; Kálmán, János; Kenny, Rose Anne; Cregg, Fiona; O'Dwyer, Sarah; Walsh, Cathal; Adams, Jessica; Banzi, Rita; Breuilh, Laetitia; Daly, Leslie; Hendrix, Suzanne; Aisen, Paul; Gaynor, Siobhan; Sheikhi, Ali; Taekema, Diana G.; Verhey, Frans R.; Nemni, Raffaello; Nobili, Flavio; Franceschi, Massimo; Frisoni, Giovanni; Zanetti, Orazio; Konsta, Anastasia; Anastasios, Orologas; Nenopoulou, Styliani; Tsolaki-Tagaraki, Fani; Pakaski, Magdolna; Dereeper, Olivier; de la Sayette, Vincent; Sénéchal, Olivier; Lavenu, Isabelle; Devendeville, Agnés; Calais, Gauthier; Crawford, Fiona; Mullan, Michael (Public Library of Science, 2018)
    Background This study reports the findings of the first large-scale Phase III investigator-driven clinical trial to slow the rate of cognitive decline in Alzheimer disease with a dihydropyridine (DHP) calcium channel ...
  • Leahy, Joe; O'Leary, Aisling; Afdhal, Nezam; Gray, Emma; Milligan, Scott; Wehmeyer, Malte H.; Walsh, Cathal (Wiley and Sons Ltd, 2018)
    The use of individual patient data (IPD) in network meta-analysis (NMA) is becoming increasingly popular. However, as most studies do not report IPD, most NMAs are performed using aggregate data for at least some, if not ...
  • Lynch, Julie; Prihodova, Lucia; Dunne, Pádraic J.; O'Leary, Caoimhe; Breen, Rachel; Carroll, Áine; Walsh, Cathal Dominic; McMahon, Geraldine; White, Barry (BMJ Publishing Group, 2018)
    Objectives Rates of burnout and stress in healthcare practitioners are steadily increasing. Emergency department (ED) staff are particularly susceptible to such poor outcomes. Mantra meditation (MM) may contribute to ...
  • Walsh, Mary E.; Galvin, Rose; Williams, David JP.; Harbison, Joseph A.; Murphy, Sean; Collins, Ronan; McCabe, Dominick JH.; Crowe, Morgan; Horgan, Frances N. (SAGE Publications, 2018)
    Introduction: Falls are common post-stroke adverse events. This study aimed to describe the first-year falls incidence, circumstances and consequences among persons discharged home after stroke in Ireland, and to examine ...
  • Walsh, Mary E.; Sorensen, Jan; Galvin, Rose; Williams, David JP.; Harbison, Joseph A.; Murphy, Sean; Collins, Ronan; McCabe, Dominick JH.; Crowe, Morgan; Horgan, Frances N. (SAGE Publications, 2018)
    Introduction: Falls are common post-stroke events but their relationship with healthcare costs is unclear. The aim of this study was to examine the relationship between healthcare costs in the first year after stroke and ...
  • Day, John P.; Whiteley, Ellanor; Freeley, Michael; Long, Aideen; Malacrida, Beatrice; Kiely, Patrick A.; Baillie, George S. (Future Science, 2018)
    Aim: RACK1 is a multifunctional scaffolding protein that is expressed in many cellular compartments, orchestrating a number of signaling processes. RACK1 acts as a signaling hub to localize active enzymes to discrete ...
  • Ng, Kwok W.; Rintala, Pauli; Husu, Pauliina; Villberg, Jari; Vasankari, Tomi; Kokko, Sami (Elsevier, 2018)
    Background: Monitoring physical activity among young adolescents with disabilities is a top academic priority. People with disabilities are a diverse group with various abilities in different human functioning. Therefore, ...
  • Brick, Noel E.; Campbell, Mark J.; Sheehan, Rachel B.; Fitzpatrick, Ben L.; MacIntyre, Tadhg E. (Taylor and Francis, 2018)
    This study examined the metacognitive processes and attentional focus of recreational endurance runners. The emphasis was on understanding the metacognitive processes important to acquire, develop, and refine cognitive ...
  • Stack, Austin G.; Li, Xia; Kaballo, Mohamed; Elsayed, Mohamed E.; Johnson, Howard; Murray, Patrick T.; Saran, Rajiv; Browne, Leonard D. (Oxford University Press, 2018)
    Background. Complete ascertainment of the true rates of acute kidney injury (AKI) and emerging trends are essential for planning of preventive strategies within health systems. Methods. We conducted a retrospective ...
  • Collins, Catríona M.; Malacrida, Beatrice; Burke, Colin; Kiely, Patrick A.; Dunleavy, Elaine M. (Nature Publishing Group, 2018)
    The histone H3 variant CENP-A epigenetically defines the centromere and is critical for chromosome segregation. Here we report an interaction between CENP-A and subunits of the mitochondrial ATP synthase complex in the ...
  • Collins, John D.; O'Sullivan, Leonard (BioMed Central, 2018)
    Background: Injury prevalence data commonly indicate trends of higher rates of work-related musculoskeletal disorders in older workers over their younger counterparts, and for females more than males. The purpose of ...
  • Schmitz, Susanne; Maguire, Áine; Morris, James; Ruggeri, Kai; Haller, Elisa; Kuhn, Isla; Leahy, Joy; Homer, Natalia; Khan, Ayesha; Bowden, Jack; Buchanan, Vanessa; O'Dwyer, Michael; Cook, Gordon; Walsh, Cathal Dominic (BioMed Central, 2018)
    Background: Network meta-analysis (NMA) allows for the estimation of comparative effectiveness of treatments that have not been studied in head-to-head trials; however, relative treatment effects for all interventions can ...
  • Hagmeyer, Simone; Sauer, Ann Katrin; Grabrucker, Andreas M. (Frontiers Media, 2018)
    The loss of one copy of SHANK3 (SH3 and multiple ankyrin repeat domains 3) in humans highly contributes to Phelan McDermid syndrome (PMDS). In addition, SHANK3 was identified as a major autism candidate gene. Interestingly, ...
  • Vilella, Antonietta; Belletti, Daniela; Sauer, Ann Katrin; Hagmeyer, Simone; Sarowar, Tasnuva; Masoni, Martina; Stasiak, Natalia; Mulvihill, John J.; Ruozi, Barbara; Forni, Flavio; Vandelli, Maria Angela; Tosi, Giovanni; Zoli, Michele; Grabrucker, Andreas M. (Elsevier, 2017)
    A local dyshomeostasis of zinc ions in the vicinity of amyloid aggregates has been proposed in Alzheimer’s disease (AD) due to the sequestration of zinc in senile plaques. While an increase in zinc levels may promote the ...
  • Vancampfort, Davy; Stubbs, Brendon; Smith, Lee; Hallgren, Mats; Firth, Joseph; Herring, Matthew P.; Probst, Michel; Koyanagi, Ai (Elsevier, 2018)
    Objective: Although physical activity (PA) is associated with a reduction of a wide range of sleep problems, it remains uncertain whether complying with the international guidelines of 150 min of moderate to vigorous PA ...
  • Kumar A. U., Arun; Browne, Leonard D.; Li, Xia; Adeeb, Fahd; Perez-Ruiz, Fernando; Fraser, Alexander D.; Stack, Austin G. (Public Library of Science, 2018)
    Background Elevated serum uric acid (sUA) concentrations are common in the general population and are associated with chronic metabolic conditions and adverse clinical outcomes. We evaluated secular trends in the burden ...
  • Davis, Niall Francis; Cunnane, Eoghan M.; Mooney, Rory; Forde, James C.; Walsh, Michael T. (Elsevier, 2018)
    OBJECTIVE: To evaluate the feasibility of a novel “safety-valve” device for preventing catheter related urethral trauma during urethral catheterization (UC). To assess the opinions of clinicians on the performance of the ...
  • Sheehan, Rachel B.; Herring, Matthew P.; Campbell, Mark J. (Elsevier, 2018)
    Objectives: This study characterised mental health, motivation, and their interrelations among 38 elite studentathletes over a 13-week season, while monitoring and considering the influence of their athletic and ...
  • Belletti, Daniela; Grabrucker, Andreas M.; Pederzoli, Francesca; Menrath, Isabel; Vandelli, Maria Angela; Tosi, Giovanni; Duskey, Thomas Jason; Forni, Flavio; Ruozi, Barbara (Elsevier, 2018)
    Restoration of the Chol homeostasis in the Central Nervous System (CNS) could be beneficial for the treatment of Huntington's Disease (HD), a progressive, fatal, adult-onset, neurodegenerative disorder. Unfortunately, Chol ...

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