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  • Pederzoli, Francesca; Ruozi, Barbara; Duskey, Jason; Hagmeyer, Simone; Sauer, Ann Katrin; Grabrucker, Stefanie; Coelho, Romina; Oddone, Natalia; Ottonelli, Ilaria; Daini, Eleonora; Zoli, Michele; Vandelli, Maria Angela; Tosi, Giovanni; Grabrucker, Andreas M. (MDPI, 2019)
    The accumulation of amyloid β (Aβ) triggers a cascade of toxic events in Alzheimer’s disease (AD). The KLVFF peptide can interfere with Aβ aggregation. However, the peptide suffers from poor bioavailability and the inability ...
  • Lawlor, Brian; Segurado, Ricardo; Kennelly, Sean; Olde Rikkert, Marcel G. M.; Howard, Robert; Pasquier, Florence; Borjesson-Hanson, Anne; Tsolaki, Magda; Lucca, Ugo; William Molloy, D; Coen, Robert; Riepe, Matthias W.; Kálmán, János; Kenny, Rose Anne; Cregg, Fiona; O'Dwyer, Sarah; Walsh, Cathal Dominic; Adams, Jessica; Banzi, Rita; Breuilh, Laetitia; Daly, Leslie; Hendrix, Suzanne; Aisen, Paul; Gaynor, Siobhan; Sheikhi, Ali; Taekema, Diana G.; Verhey, Frans R.; Nemni, Raffaello; Nobili, Flavio; Franceschi, Massimo; Frisoni, Giovanni; Zanetti, Orazio; Konsta, Anastasia; Anastasios, Orologas; Nenopoulou, Styliani; Tsolaki-Tagaraki, Fani; Pakaski, Magdolna; Dereeper, Olivier; de la Sayette, Vincent; Sénéchal, Olivier; Lavenu, Isabelle; Devendeville, Agnés; Calais, Gauthier; Crawford, Fiona; Mullan, Michael (Public Library of Science, 2018)
    Background This study reports the findings of the first large-scale Phase III investigator-driven clinical trial to slow the rate of cognitive decline in Alzheimer disease with a dihydropyridine (DHP) calcium channel ...
  • Bashar, Khalid; Healy, Donagh A.; Elsheikh, Sawsan; Browne, Leonard D.; Walsh, Michael T.; Clarke-Moloney, Mary; Burke, Paul E.; Kavanagh, Eamon G.; Walsh, Stewart R. (Public Library of Science, 2015)
    A brachiobasilic arteriovenous fistula (BB-AVF) can provide access for haemodialysis in patients who are not eligible for a more superficial fistula. However, it is unclear whether one or two-stage BB-AVF is the best option ...
  • Murphy, Sylvia M.; Kiely, Maeve; Jakeman, Philip M.; Kiely, Patrick A.; Carson, Brian P. (Portland Press, 2016)
    The importance of growth and maintenance of skeletal muscle is vital for long term health and quality of life. Appropriate nutrition with specific bioactivities relevant to the functionalities of tissues such as skeletal ...
  • Konstantinos, Siontis C.; Zhang, Xiaosong; Eckard, Ashley; Bhave, Nicole; Schaubel, Douglas E.; He, Kevin; Tilea, Anca; Stack, Austin G.; Balkrishnan, Rajesh; Yao, Xiaoxi; Noseworthy, Peter A.; Shah, Nilay D.; Saran, Rajiv; Nallamothu, Brahmajee K. (Lippincott, Williams & Wilkins, 2018)
    Background: Patients with end-stage kidney disease (ESKD) on dialysis were excluded from clinical trials of direct oral anticoagulants for atrial fibrillation (AF). Recent data have raised concerns regarding the safety ...
  • McMahon, Grace; Creaven, Ann-Marie; Gallagher, Stephen (Wiley and Sons Ltd, 2019)
    To understand the influence of social relationships on cardiovascular responses to stress, the present study investigated perceived affectionate support as a mediating variable explaining the association between specific ...
  • Manning, Molly; MacFarlane, Anne E.; HIckey, Anne; Franklin, Sue (Public Library of Science, 2019)
    Background There is increased focus on supporting people with chronic conditions to live well via person- centred, integrated care. There is a growing body of qualitative literature examining the insider perspectives ...
  • Vancampfort, Davy; Stubbs, Brendon; Smith, Lee; Hallgren, Mats; Firth, Joseph; Herring, Matthew P.; Probst, Michel; Koyanagi, Ai (Elsevier, 2018)
    Objective: Although physical activity (PA) is associated with a reduction of a wide range of sleep problems, it remains uncertain whether complying with the international guidelines of 150 min of moderate to vigorous PA ...
  • Glynn, Liam G.; Mustafa, Alaa; Casey, Monica; Krawczyk, Janusz; Blom, Jeanete; Galvin, Rose; Hannigan, Ailish; Dunne, Colum P.; Murphy, Andrew W.; Mallen, Christian (BioMed Central, 2018)
    Background: Platelet-rich plasma (PRP) is a concentrate of autologous blood growth factors which has been shown to provide some symptomatic relief in early osteoarthritis (OA) of the knee. The objective of this study was ...
  • Healy, Donagh A.; Clarke-Moloney, Mary; Gaughan, Brendan; O'Daly, Siobhan; Hausenloy, Derek; Sharif, Faisal; Newell, John; O'Donnell, Martin; Grace, Pierce; Forbes, John F.; Cullen, Walter; Kavanagh, Eamon G.; Burke, Paul E.; Cross, Simon; Dowdall, Joseph; McMonagle, Morgan; Fulton, Greg J.; Manning, Brian J; Kheirelseid, Elrasheid A. H.; Leahy, Austin; Moneley, Daragh; Naughton, Peter; Boyle, Emily; McHugh, Seamus; Madhaven, Prakash; O'Neill, Sean; Martin, Zenia; Courtney, Donal; Tubassam, Muhammed; Sultan, Sherif; McCartan, Damian; Medani, Mekki; Walsh, Stewart R. (BioMed Central, 2015)
    Background: Patients undergoing vascular surgery procedures constitute a 'high-risk' group. Fatal and disabling perioperative complications are common. Complications arise via multiple aetiological pathways. This mechanistic ...
  • Cunnane, Connor V.; Cunnane, Eoghan M.; Moran, Daniel T.; Walsh, Michael T. (Wiley and Sons Ltd, 2019)
    Areas of disturbed shear that develop following arteriovenous fistula (AVF) creation are believed to trigger the onset of intimal hyperplasia (IH), leading to AVF dysfunction. The presence of helical flow can suppress the ...
  • McCormack, Hannah M.; MacIntyre, Tadhg E.; O'Shea, Deirdre; Herring, Matthew P.; Campbell, Mark J. (Frontiers Media, 2018)
    Purpose: Burnout has been shown to develop due to chronic stress or distress, which has negative implications for both physical and mental health and well-being. Burnout research originated in the “caring-professions.” ...
  • Hussein, Wael F.; Mohammed, Husham; Browne, Leonard D.; Plant, Liam; Stack, Austin G. (BioMed Central, 2018)
    Background: Central venous catheters (CVC) are associated with substantial morbidity and mortality among patients undergoing haemodialysis (HD), yet they are frequently used as the primary vascular access for many patients ...
  • Mohammed, Elshaeima; Browne, Leonard D.; Kumar A. U., Arun; Adeeb, Fahd; Fraser, Alexander D.; Stack, Austin G. (Public Library of Science, 2019)
    Gout is a common inflammatory arthritis associated with adverse clinical outcomes. Under treatment is common in the general population. The aim of this study was to determine the prevalence of gout and its treatment among ...
  • Wolter, Maike; Volkert, Dorothee; Streicher, Melanie; Kiesswetter, Eva; Torbahn, Gabriel; O'Connor, Eibhlís M.; O'Keeffe, Mary; Kelly, Mary; O'Herlihy, Eileen A.; O'Toole, Paul W.; Timmons, Suzanne; O'Shea, Emma; Kearney, Patricia M.; van Zwienen-Pot, Judith; Visser, Marjolein; Maitre, Isabelle; Van Wymelbeke, Virginie; Sulmont-Rossé, Claire; Nagel, Gabriele; Flechtner-Mors, Marion; Goisser, Sabine; Teh, Ruth; Hebestreit, Antje (Elsevier, 2018)
    Background & aims: Malnutrition is widespread among older people and related to poor outcome. Reported prevalences vary widely, also because of different diagnostic criteria used. This study aimed to describe prevalences ...
  • O'Riordan, David; Elodie Aubert, Carole; Walsh, Kieran A.; Van Dorland, Anette; Rodondi, Nicolas; Du Puy, Robert S.; Poortvliet, Rosalinde K E.; Gussekloo, Jacobijn; Sinnott, Carol; Byrne, Stephen; Galvin, Rose; Jukema, J Wouter; Mooijaart, Simon P.; Baumgartner, Christine; McCarthy, Vera J.C.; Walsh, Elaine K.; Collet, Tinh-Hai; Dekkers, Olaf M.; Blum, Manuel R.; Kearney, Patricia M. (BMJ Publishing Group, 2018)
    Objectives To estimate and compare the prevalence and type of potentially inappropriate prescribing (PIP) and potential prescribing omissions (PPOs) among communitydwelling older adults (≥65 years) enrolled to a clinical ...
  • Hagmeyer, Simone; Sauer, Ann Katrin; Grabrucker, Andreas M. (Frontiers Media, 2018)
    The loss of one copy of SHANK3 (SH3 and multiple ankyrin repeat domains 3) in humans highly contributes to Phelan McDermid syndrome (PMDS). In addition, SHANK3 was identified as a major autism candidate gene. Interestingly, ...
  • Dowling, Catríona M.; Phelan, James L.; Callender, Julia A.; Cathcart, Mary Clare; Mehigan, Brian; McCormick, Paul; Dalton, Tara; Coffey, John C.; Newton, Alexandra C.; O'Sullivan, Jacintha; Kiely, Patrick A. (Impact Journals, 2016)
    Despite extensive efforts, cancer therapies directed at the Protein Kinase C (PKC) family of serine/threonine kinases have failed in clinical trials. These therapies have been directed at inhibiting PKC and have, in some ...
  • Flygaard, Rasmus Kock; Malacrida, Beatrice; Kiely, Patrick A.; Jenner, Lasse Bohl (Elsevier, 2019)
    Human elongation factor 2 is the translocase that is responsible for the movement of tRNA from the A- to P- and P- to E-site on the ribosome during the elongation phase of translation. Being a vital factor of protein ...
  • Stack, Austin G.; Alghali, Ahmed; Li, Xia; Ferguson, John P.; Casserly, Liam F.; Cronin, Cornelius J.; Reddan, Donal N.; Hussein, Wael F.; Elsayed, Mohamed E. (Oxford University Press, 2017)
    Background: Although anaemia is a common complication of advanced chronic kidney disease (CKD), knowledge of quality of care and management practices in specialist clinics varies. We examined anaemia practices at specialist ...

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