Thomas, Valentina; Cotter, Maura B.; Tosetto, Miriam; Khaw, Yi Ling; Geraghty, Robert; Winter, Desmond C; Ryan, Elizabeth J.; Sheahan, Kieran; Furney, Simon J.(Nature Research, 2020)
Synchronous colorectal cancers (syCRCs) are two or more primary tumours identified
simultaneously in a patient. Previous studies report high inter-tumour heterogeneity
between syCRCs, suggesting independent origin and ...
Mahdi, Amira F.; Malacrida, Beatrice; Nolan, Joanne; McCumiskey, Mary E; Merrigan, Anne B.; Lal, Ashish; Tormey, Shona; Lowery, Aoife J; McGourty, Kieran; Kiely, Patrick A.(MDPI, 2020)
When breast cancer progresses to a metastatic stage, survival rates decline rapidly
and it is considered incurable. Thus, deciphering the critical mechanisms of metastasis
is of vital importance to develop new treatment ...
O'Leary, Noreen; Salmon, Nancy; Clifford, Amanda M.(Taylor and Francis, 2020)
Theoretical frameworks add depth to research and increase the transferability of findings. Unfortunately, theory application within interprofessional research is often ad hoc, superficial and poorly reported. Consequently, ...
Background: Only 10–30% of oesophageal and rectal adenocarcinoma patients treated with neoadjuvant chemoradiotherapy have a complete pathological response. Inflammatory and angiogenic mediators in the tumour microenvironment ...
O'Keeffe, M; Kelly, M; O'Herlihy, E; O'Toole, P.W.; Kearney, P.M.; Timmons, Suzanne; O'Shea, E; Stanton, C; Hickson, M; Rolland, Y; Rosse, Sulmont; Issanchou, S; Maitre, I; Stelmach-Mardas, M; Nagel, G; Flechtner-Mors, M; Wolters, M; Hebestreit, A; De Groot, L.C.P.G.M; van de Rest, O; Teh, R; Peyron, M.A; Dardevet, D; Papet, I; Schindler, K; Streicher, M; Torbahn, G; Kiesswetter, E; Visser, M; Volkert, D; O'Connor, E.M; *on behalf of the MaNuEL consortium(Elsevier, 2019)
Background & aims: Malnutrition in older adults results in significant personal, social, and economic burden. To combat this complex, multifactorial issue, evidence-based knowledge is needed on the modifiable determinants ...
Zamboni, Fernanda; Ryan, Elizabeth J.; Culebras, Mario; Collins, Maurice N.(Elsevier, 2020)
Here, we synthesise a new isocyanate-based crosslinker with the aim of obtaining novel tailored gels. The newly crosslinked hyaluronic acid (HA) gels were analysed in terms of rheological properties, chemical structure, ...
Amigo-Benavent, Miryam; Power-Grant, Orla; FitzGerald, Richard J.; Jakeman, Phil(Elsevier, 2020)
Independent of glucose, ingestion of protein evokes an insulinotropic response due to enterogastric incretin hormones and hyperaminoacidemia. The aim of this study was to characterise insulin and incretin secretion in ...
O'Keeffe, Brendan T.; MacDonncha, Ciaran; Donnelly, Alan Edward(SAGE Publications, 2020)
The aim of this study was to examine secondary school students’ attitudes towards and experiences of a student-centred health-related fitness test battery. A total of 795 adolescents (403 boys, 50.7%; 392 girls, 49.3%) ...
Background: Medical School programme workloads challenge the physical and mental health of students particularly in compressed graduate entry programmes. There is evidence that physical activity (PA) can improve holistic ...
Dennis, Martin; Forbes, John F.; Graham, Catriona; Hackett, Maree; Hankey, Graeme J; House, Allan; Lewis, Stephanie; Lundström, Erik; Sandercock, Peter; Mead, Gillian on behalf of the FOCUS Trial Collaboration,(NIHR Journals Library, 2020)
Background: Our Cochrane review of selective serotonin inhibitors for stroke recovery indicated that fluoxetine may improve functional recovery, but the trials were small and most were at high risk of bias. Objectives: The ...
Ross, Aisling M.; Kennedy, Tadhg; McNulty, David; Leahy, Ciara I.; Walsh, Darragh R.; Murray, Paul; Grabrucker, Andreas M.; Mulvihill, John J.E.(Elsevier, 2020)
Delivering therapeutics to disease sites is a challenge facing modern medicine. Nanoparticle delivery systems are of considerable interest to overcome this challenge, but these systems suffer from poor clinical translation. ...
Anterior cruciate ligament (ACL) injuries are common among athletes. Despite a successful return to sport (RTS) for most of the injured athletes, a significant proportion do not return to competitive levels, and thus RTS ...
Leahy, Joe; Thom, Howard; Jansen, Jeroen P; Gray, Emma; O'Leary, Aisling; White, Arthur; Walsh, Cathal Dominic(Wiley and Sons Ltd, 2019)
Increasingly, single-armed evidence is included in health technology assessment submissions when companies are seeking reimbursement for new drugs. While it is recognized that randomized controlled trials provide a higher ...
. Recent research suggests that gratitude is associated with better cardiovascular health. Here, we investigated whether trait and/or state gratitude was associated with cardiovascular responses to acute stress. Eighty-six ...
Kermavnar, Tjaša; O'Sullivan, Kevin Jeremiah; de Eyto, Adam; O'Sullivan, Leonard(Taylor and Francis, 2020)
There is a lack of data and guidance on soft exoskeleton pressure contact with the body. The purpose of this research was to study the relationship between circumferential loading at the knee and discomfort/pain, to inform ...
The novel coronavirus disease (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has engulfed the world, affecting more than 180 countries. As a result, there has been considerable ...
Kalb, Rosalind; Brown, Theodore R; Coote, Susan; Costello, , Kathleen; Dalgas, Ulrik; Garmon, Eric; Giesser, Barbara; Halper, June; Karpatkin, Herb; Keller, Jennifer; Ng, Alexander V; Pilutti, Lara A; Rohrig, Amanda; Van Asch, Paul; Zackowski, Kathleen; Motl, Robert W(Sage and Open Access, 2020)
Objectives: To provide clinicians who treat multiple sclerosis (MS) patients with evidence-based or expert opinion–based recommendations for promoting exercise and lifestyle physical activity across disability levels. ...
Mental health in the workplace is a societal challenge with serious economical and human
costs. Most prevalent mental disorders in the workforce (e.g., depression), however, are
preventable. There is widespread agreement ...
BACKGROUND: Shoulder pain is a common musculoskeletal complaint and disorders of the rotator cuff (RC) are widely regarded as the most common cause. Where clinical care is required, physiotherapists play an integral role. ...
Objectives
Discrete choice experiments (DCEs) are used in healthcare to measure the relative importance that stakeholders give to different features (or attributes) of medical treatments or services. They may also help ...