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Browsing Research Institutes, Centres and Units by Author "O'Sullivan, Jacintha"

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Browsing Research Institutes, Centres and Units by Author "O'Sullivan, Jacintha"

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  • Dowling, Catríona M.; Hayes, Sheri L.; Phelan, James L.; Cathcart, Mary Clare; Finn, Stephen P.; Mehigan, Brian; McCormick, Paul; Coffey, Calvin J.; O'Sullivan, Jacintha; Kiely, Patrick A. (Impact Journals, 2017)
    Despite extensive efforts, Protein Kinase Cs (PKCs) have proven to be an intractable target in cancer therapies. Traditionally it was accepted that PKCs act as tumour promoters, however new research suggests that PKCs ...
  • Dowling, Catríona M.; Phelan, James L.; Callender, Julia A.; Cathcart, Mary Clare; Mehigan, Brian; McCormick, Paul; Dalton, Tara; Coffey, Calvin J.; Newton, Alexandra C.; O'Sullivan, Jacintha; Kiely, Patrick A. (Impact Journals, 2016)
    Despite extensive efforts, cancer therapies directed at the Protein Kinase C (PKC) family of serine/threonine kinases have failed in clinical trials. These therapies have been directed at inhibiting PKC and have, in some ...
  • Morrissey, Maria E.; Byrne, Róisín; Nulty, Celina; McCabe, Niamh H.; Lynam-Lennon, Niamh; Butler, Clare T; Kennedy, Susan; O'Toole, Dermot; Larkin, John; McCormick, Paul; Mehigan, Brian; Cathcart, Mary-Clare; Lysaght, Joanne; Reynolds, John V.; Ryan, Elizabeth J.; Dunne, Margaret R.; O'Sullivan, Jacintha (BMC, 2020)
    Background: Only 10–30% of oesophageal and rectal adenocarcinoma patients treated with neoadjuvant chemoradiotherapy have a complete pathological response. Inflammatory and angiogenic mediators in the tumour microenvironment ...

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