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Browsing Research Institutes, Centres and Units by Author "Kiely, Patrick A."

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Browsing Research Institutes, Centres and Units by Author "Kiely, Patrick A."

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  • Collins, Catríona M.; Malacrida, Beatrice; Burke, Colin; Kiely, Patrick A.; Dunleavy, Elaine M. (Nature Publishing Group, 2018)
    The histone H3 variant CENP-A epigenetically defines the centromere and is critical for chromosome segregation. Here we report an interaction between CENP-A and subunits of the mitochondrial ATP synthase complex in the ...
  • Zamboni, Fernanda; Keays, Marie; Hayes, Sheri; Albadarin, Ahmad B.; Walker, Gavin M.; Kiely, Patrick A.; Collins, Maurice N. (Elsevier, 2017)
    The concept of the present work is to produce porous optimised scaffolds of poly(lactic-co-glycolic acid) (PLGA) coated with hyaluronic acid (HA), to provide a suitable microenvironment for cellular proliferation. Freeze ...
  • Dowling, Catríona M.; Hayes, Sheri L.; Phelan, James L.; Cathcart, Mary Clare; Finn, Stephen P.; Mehigan, Brian; McCormick, Paul; Coffey, John C.; O'Sullivan, Jacintha; Kiely, Patrick A. (Impact Journals, 2017)
    Despite extensive efforts, Protein Kinase Cs (PKCs) have proven to be an intractable target in cancer therapies. Traditionally it was accepted that PKCs act as tumour promoters, however new research suggests that PKCs ...
  • Hayes, Christopher J.; Dowling, Catríona M.; Dwane, Susan; McCumiskey, Mary E.; Tormey, Shona M.; Merrigan, Anne; Coffey, John C.; Kiely, Patrick A.; Dalton, Tara (AIP Publishing, 2016)
    In cancer, biomarkers have many potential applications including generation of a differential diagnosis, prediction of response to treatment, and monitoring disease progression. Many molecular biomarkers have been put ...
  • Murphy, Sylvia M.; Kiely, Maeve; Jakeman, Philip M.; Kiely, Patrick A.; Carson, Brian P. (Portland Press, 2016)
    The importance of growth and maintenance of skeletal muscle is vital for long term health and quality of life. Appropriate nutrition with specific bioactivities relevant to the functionalities of tissues such as skeletal ...
  • Dowling, Catríona M.; Phelan, James L.; Callender, Julia A.; Cathcart, Mary Clare; Mehigan, Brian; McCormick, Paul; Dalton, Tara; Coffey, John C.; Newton, Alexandra C.; O'Sullivan, Jacintha; Kiely, Patrick A. (Impact Journals, 2016)
    Despite extensive efforts, cancer therapies directed at the Protein Kinase C (PKC) family of serine/threonine kinases have failed in clinical trials. These therapies have been directed at inhibiting PKC and have, in some ...
  • Flygaard, Rasmus Kock; Malacrida, Beatrice; Kiely, Patrick A.; Jenner, Lasse Bohl (Elsevier, 2019)
    Human elongation factor 2 is the translocase that is responsible for the movement of tRNA from the A- to P- and P- to E-site on the ribosome during the elongation phase of translation. Being a vital factor of protein ...
  • Day, John P.; Whiteley, Ellanor; Freeley, Michael; Long, Aideen; Malacrida, Beatrice; Kiely, Patrick A.; Baillie, George S. (Future Science, 2018)
    Aim: RACK1 is a multifunctional scaffolding protein that is expressed in many cellular compartments, orchestrating a number of signaling processes. RACK1 acts as a signaling hub to localize active enzymes to discrete ...
  • Kiely, Maeve; Adams, David R.; Hayes, Sheri L.; O'Connor, Rosemary; Baillie, George S.; Kiely, Patrick A. (Elsevier, 2017)
    Conflicting reports implicate the scaffolding protein RACK1 in the progression of breast cancer. RACK1 has been identified as a key regulator downstream of growth factor and adhesion signalling and as a direct binding ...
  • Dowling, Catríona M.; Kiely, Patrick A. (MDPI, 2015)
    The signaling outputs of Receptor Tyrosine Kinases, G-protein coupled receptors and integrins converge to mediate key cell process such as cell adhesion, cell migration, cell invasion and cell proliferation. Once activated ...

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