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Browsing Research Institutes, Centres and Units by Author "Dowling, Catríona M."

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Browsing Research Institutes, Centres and Units by Author "Dowling, Catríona M."

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  • Dowling, Catríona M.; Hayes, Sheri L.; Phelan, James L.; Cathcart, Mary Clare; Finn, Stephen P.; Mehigan, Brian; McCormick, Paul; Coffey, Calvin J.; O'Sullivan, Jacintha; Kiely, Patrick A. (Impact Journals, 2017)
    Despite extensive efforts, Protein Kinase Cs (PKCs) have proven to be an intractable target in cancer therapies. Traditionally it was accepted that PKCs act as tumour promoters, however new research suggests that PKCs ...
  • Hayes, Christopher J.; Dowling, Catríona M.; Dwane, Susan; McCumiskey, Mary E.; Tormey, Shona M.; Merrigan, Anne; Coffey, Calvin J.; Kiely, Patrick A.; Dalton, Tara (AIP Publishing, 2016)
    In cancer, biomarkers have many potential applications including generation of a differential diagnosis, prediction of response to treatment, and monitoring disease progression. Many molecular biomarkers have been put ...
  • Dowling, Catríona M.; Phelan, James L.; Callender, Julia A.; Cathcart, Mary Clare; Mehigan, Brian; McCormick, Paul; Dalton, Tara; Coffey, Calvin J.; Newton, Alexandra C.; O'Sullivan, Jacintha; Kiely, Patrick A. (Impact Journals, 2016)
    Despite extensive efforts, cancer therapies directed at the Protein Kinase C (PKC) family of serine/threonine kinases have failed in clinical trials. These therapies have been directed at inhibiting PKC and have, in some ...
  • Dowling, Catríona M.; Kiely, Patrick A. (MDPI, 2015)
    The signaling outputs of Receptor Tyrosine Kinases, G-protein coupled receptors and integrins converge to mediate key cell process such as cell adhesion, cell migration, cell invasion and cell proliferation. Once activated ...

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