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The striopallidal neuron: a main locus for adenosine-dopamine innteractions in the brain

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Show simple item record Ferré, Sergi O'Connor, William T. Fuxe, Kjell Ungerstedt, Urban 2015-06-18T10:29:21Z 2015-06-18T10:29:21Z 1993
dc.description peer-reviewed en_US
dc.description.abstract Recent pharmacological data suggest that a receptor-receptor interaction between adenosine A2 and dopamine O2 receptors in the brain underlies the behavioral effects of adenosine agonists and adenosine antagonists, such as caf· feine and theophylline. According to this interaction, stimulation of A2 receptors inhibits and their blockade potentiates the effects of O2 receptor stimulation. Furthermore, both A2 and O2 receptors are selectively colocalized on GABAergic striopallidal neurons. In this microdialysis investigation the effect of intra striatal infusion of adenosine and dopamine agonists and antagonists alone or in combination was studied on the release of GABA from the terminals of the striopallidal neuron in awake, freely moving rats. We report that the GABAergic striopallidal neuron, which is a key component of the indirect striatal efferent pathway, is a main locus for A2-02 interactions in the brain and possibly a main target for the central actions of adenosine agonists and antagonists. en_US
dc.language.iso eng en_US
dc.publisher Society for Neuroscience en_US
dc.relation.ispartofseries The Journal of Neuroscience;13 (12), pp. 5402-5406
dc.subject adenosine A en_US
dc.subject receptor en_US
dc.subject dopamine D en_US
dc.subject GABA en_US
dc.subject striopallidal neuron en_US
dc.title The striopallidal neuron: a main locus for adenosine-dopamine innteractions in the brain en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US

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