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The striatal neurotensin receptor modulates striatal and pallidal glutamate and GABA release: functional evidence for a pallidal glutamate–GABA interaction via the pallidal–subthalamic nucleus loop

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dc.contributor.author Ferraro, Luca
dc.contributor.author Antonelli, Tiziana
dc.contributor.author O'Connor, William T.
dc.contributor.author Fuxe, Kjell
dc.contributor.author Soubrié, Philippe
dc.contributor.author Tanganelli, Sergio
dc.date.accessioned 2015-06-18T08:32:20Z
dc.date.available 2015-06-18T08:32:20Z
dc.date.issued 1998
dc.identifier.uri http://hdl.handle.net/10344/4495
dc.description peer-reviewed en_US
dc.description.abstract In the present study, we used dual-probe microdialysis to investigate the effects of intrastriatal perfusion with neurotensin (NT) on striatal and pallidal glutamate and GABA release. The role of the pallidal GABAA receptor in the intrastriatal NTinduced increase in pallidal glutamate release was also investigated. Intrastriatal NT (100 and 300 nM) increased striatal glutamate and GABA (100 nM, 155 6 9 and 141 6 6%, respectively; 300 nM, 179 6 8 and 166 6 11%, respectively) release, as well as pallidal glutamate and GABA (100 nM, 144 6 8 and 130 6 5%; 300 nM, 169 6 9 and 157 6 8%, respectively) release. These effects were dose-dependently antagonized by the NT receptor antagonist 2-[(1-(7-chloro-4-quinolinyl)- 5-(2,6-dimethoxy-phenyl)pyrazol-3-yl)carboxylamino]tricyclo) 3.3.1.1.3.7)-decan-2-carboxylic acid (SR48692). Intrasubthalamic injection of the GABAA receptor antagonist (2)-bicuculline (10 pmol/100 nl, 30 sec) rapidly increased pallidal glutamate release, whereas the intrastriatal NT-induced increase in pallidal glutamate release was counteracted by intrapallidal perfusion with (2)-bicuculline, suggesting that an increase in striopallidal GABA-mediated inhibition of the GABAergic pallidal–subthalamic pathway results in an increased glutamatergic drive in the subthalamic–pallidal pathway. These results demonstrate a tonic pallidal GABA-mediated inhibition of excitatory subthalamic–pallidal neurons and strengthen the evidence for a functional role of NT in the regulation of glutamate and GABA transmission in the basal ganglia. The ability of intrastriatal SR48692 to counteract the NT-induced increase in both striatal and pallidal glutamate and GABA release suggests that blockade of the striatal NT receptor may represent a possible new therapeutic strategy in the treatment of those hypokinetic disorders implicated in disorders of the indirect pathway mediating motor inhibition en_US
dc.language.iso eng en_US
dc.publisher Society for Neuroscience en_US
dc.relation.ispartofseries The Journal of Neuroscience;18, (17), pp. 6977-6989
dc.relation.uri http://www.jneurosci.org/content/18/17/6977.full.pdf+html
dc.subject basal ganglia en_US
dc.subject striatum en_US
dc.subject neurotensin en_US
dc.subject SR48692 en_US
dc.subject microdialysis en_US
dc.subject awake rat en_US
dc.title The striatal neurotensin receptor modulates striatal and pallidal glutamate and GABA release: functional evidence for a pallidal glutamate–GABA interaction via the pallidal–subthalamic nucleus loop en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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