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A case of Panton–Valentine leucocidin toxin-positive staphylococcus aureus-mediated neonatal mastitis

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Show simple item record O'Connor, Ciara O'Connell, Nuala H. Power, Lorraine Merrigan, Anne Tormey, Shona M. Coffey, Calvin J. Linnane, Barry Dunne, Colum P. 2015-05-28T14:12:17Z 2015-05-28T14:12:17Z 2014
dc.description peer-reviewed en_US
dc.description.abstract Introduction: Neonatal mastitis is an inflammatory condition of the breast frequently associated with Staphylococcus aureus. While Panton–Valentine leucocidin (PVL), a B-pore-forming cytotoxin, is commonly associated with enhanced virulence in community-acquired methicillinresistant S. aureus isolates, this is the first report to our knowledge of neonatal mastitis caused by PVL-positive S. aureus. Case presentation: A 20-day-old full-term female neonate presented with bilateral mastitis, complicated by bilateral abscess formation. PVL toxin-positive S. aureus was cultured from aspirates of both breasts. All family members, none of whom presented with symptoms of infection, and, specifically, maternal vaginal samples proved negative for PVL-positive S. aureus. Successful resolution involved surgical drainage and clindamycin therapy. Conclusion: While PVL toxin-positive S. aureus has previously been implicated in bovine and ovine mastitis, there may now be a need for vigilance with respect to human incidence. Due to PVL-mediated tissue necrosis, breast abscess formation and poor response to conventional antimicrobial therapy should, perhaps, be a cause for suspicion of PVL-bearing S. aureus and expediting of appropriate therapy to avoid potential for long-term consequences such as abnormal breast development. en_US
dc.language.iso eng en_US
dc.publisher Society for General Microbiology en_US
dc.relation.ispartofseries JMM Case Reports;1.3
dc.subject mastitis en_US
dc.subject neonatal en_US
dc.subject Panton–Valentine leucocidin en_US
dc.subject staphylococcus aureus en_US
dc.title A case of Panton–Valentine leucocidin toxin-positive staphylococcus aureus-mediated neonatal mastitis en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1099/jmmcr.0.004119
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1567717

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