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Clustered multidrug-resistant Bordetella petrii in adult cystic fibrosis patients in Ireland: case report and review of antimicrobial therapies

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dc.contributor.author Carleton, Ailise
dc.contributor.author Casserly, Brian
dc.contributor.author Power, Lorraine
dc.contributor.author Linnane, Barry
dc.contributor.author O'Flaherty, Grainne
dc.contributor.author Powell, James
dc.contributor.author Hartnett, Peig
dc.contributor.author Collins, Jonathan
dc.contributor.author Murphy, Philip
dc.contributor.author Kenna, Dervla
dc.contributor.author O'Connell, Nuala H.
dc.contributor.author Dunne, Colum P.
dc.date.accessioned 2015-04-09T12:08:24Z
dc.date.available 2015-04-09T12:08:24Z
dc.date.issued 2014
dc.identifier.uri http://hdl.handle.net/10344/4405
dc.description peer-reviewed en_US
dc.description.abstract Introduction: Bordetella petrii is an emerging pathogen. Whilst association with cystic fibrosis (CF) has been described previously, this is the first report to our knowledge of multidrug-resistant B. petrii incidence in an Irish CF patient population. Case presentation: Using a case series of four adult CF patients with varying baselines of health, one of whom was asymptomatic, this report attempts correlation of B. petrii colonization, by one common strain, with incidence of acute exacerbation of symptoms. As definitive guidelines for antimicrobial sensitivity/resistance do not exist for B. petrii, we completed a systematic review of available literature to collate evidence of antimicrobial efficacy against B. petrii. Comparison with the isolates in this study indicated B. petrii sensitivity to piperacillin/ tazobactam and minocycline but resistance to antimicrobials in the macrolide, other b-lactam and fluoroquinolone groups. Conclusion: To our knowledge, this is the first report of multiple CF patients sharing a strain of B. petrii. Furthermore, B. petrii may be under-identified in CF patients and should be considered when evaluating exacerbation of CF symptoms. en_US
dc.language.iso eng en_US
dc.publisher Society for General Microbiology en_US
dc.relation.ispartofseries JMM Case Reports;1
dc.relation.uri http://jmmcr.sgmjournals.org/
dc.subject bordetella colonization en_US
dc.subject cystic fibrosis en_US
dc.subject multidrug-resistant en_US
dc.title Clustered multidrug-resistant Bordetella petrii in adult cystic fibrosis patients in Ireland: case report and review of antimicrobial therapies en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1446445


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