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Parental caregivers of children with developmental disabilities mount a poor antibody response to pneumococcal vaccination.

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dc.contributor.author Gallagher, Stephen
dc.contributor.author Phillips, Anna C.
dc.contributor.author Drayson, Mark T.
dc.contributor.author Carroll, Douglas
dc.date.accessioned 2015-03-19T12:18:06Z
dc.date.available 2015-03-19T12:18:06Z
dc.date.issued 2009
dc.identifier.citation Gallagher, S; Phillips, AC; Drayson, MT; Carroll, D (2009) 'Parental caregivers of children with developmental disabilities mount a poor antibody response to pneumococcal vaccination'. BRAIN BEHAV. IMMUN, 23 (3):338-346. en_US
dc.identifier.uri http://hdl.handle.net/10344/4372
dc.description peer-reviewed en_US
dc.description.abstract In older populations, caregiving for a spouse with dementia has been associated with a poor antibody response to vaccination. The present study examined whether younger caregivers, specifically the parents of children with developmental disabilities, would also show a diminished antibody response to vaccination. At baseline assessment, 30 parents of children with developmental disabilities and 29 parents of typically developing children completed standard measures of depression, perceived stress, social support, caregiver burden, and child problem behaviours. They also provided a blood sample and were then vaccinated with a pneumococcal polysaccharide vaccine. Further blood samples were taken at 1- and 6-month follow-ups. Caregivers mounted a poorer antibody response to vaccination than control parents at both follow-ups. This effect withstood adjustment for a number of possible confounders and appeared to be, at least in part, mediated by child problem behaviours. The negative impact of caregiving on antibody response to vaccination is not restricted to older spousal caregivers, but is also evident in younger parents caring for children with developmental disabilities. The behavioural characteristics of the care recipients may be a key consideration in whether or not immunity is compromised in this context. en_US
dc.language.iso eng en_US
dc.publisher Elsevier en_US
dc.relation.ispartofseries Brain, Behavior and Immunity;23 (3), pp. 338-346
dc.relation.uri http://dx.doi.org/10.1016/j.bbi.2008.05.006
dc.rights This is the author’s version of a work that was accepted for publication in Brain, Behavior and Immunity. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Brain, Behavior and Immunity, 23 (3), pp. 338-346, http://dx.doi.org/10.1016/j.bbi.2008.05.006 en_US
dc.subject antibody response en_US
dc.subject caregiving en_US
dc.subject children with developmental disabilities en_US
dc.subject child problem behaviours en_US
dc.subject chronic stress en_US
dc.subject pneumococcal vaccination en_US
dc.title Parental caregivers of children with developmental disabilities mount a poor antibody response to pneumococcal vaccination. en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2015-03-13T12:47:10Z
dc.description.version ACCEPTED
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1121626
dc.internal.copyrightchecked Yes
dc.identifier.journaltitle BRAIN BEHAV. IMMUN.
dc.description.status peer-reviewed


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