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A commentary on the disparate perspectives of clinical microbiologists and surgeons: ad hoc antimicrobial use.

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Show simple item record O'Connell, Nuala H. O'Connor, Ciara O'Mahony, Jim Lobo, Ronstan Hayes, Maria Masterson, Eric Larvin, Michael Coffey, Calvin J. Dunne, Colum P. 2014-11-20T17:52:14Z 2014-11-20T17:52:14Z 2014
dc.description peer-reviewed en_US
dc.description.abstract Prosthetic joints and other orthopaedic implants have improved quality of life for patients world-wide and the use of such devices is increasing. However, while infection rates subsequent to associated surgery are relatively low (<3%), the consequences of incidence are considerable, encompassing morbidity (including amputation) and mortality in addition to significant social and economic costs. Emphasis, therefore, has been placed on mitigating microbial risk, with clinical microbiologists and surgeons utilizing rapidly evolving molecular laboratory techniques in detection and diagnosis of infection, which still occurs despite sophisticated patient management. Multidisciplinary approaches are regularly adopted to achieve this. In this commentary, we describe an unusual case of Actinomyces infection in total hip arthroplasty and, in that context, describe the perspectives of the clinical microbiology and surgical teams and how they contrasted. More specifically, this case demonstrates an ad hoc approach to structured eradication of biofilms and intracellular bacteria related to biomaterials, as reflected in early usage of linezolid. This is a complex topic as, and as described in this case, such accelerated treatment can be effective. This commentary focuses on the merits of such inadvisable use of potent antimicrobials amid the risk of diminishing valuable antimicrobial efficacy, albeit resulting in desirable patient outcomes. en_US
dc.language.iso eng en_US
dc.publisher Landes Bioscience en_US
dc.relation.ispartofseries Bioengineered;5 (4), pp. 218-221
dc.subject ad hoc en_US
dc.subject antimicrobial en_US
dc.subject clinical microbiology en_US
dc.subject perspectives en_US
dc.subject surgery en_US
dc.title A commentary on the disparate perspectives of clinical microbiologists and surgeons: ad hoc antimicrobial use. en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US 2014-11-20T17:40:57Z
dc.description.version ACCEPTED
dc.identifier.doi 10.4161/bioe.28722
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1560849
dc.internal.copyrightchecked Yes
dc.description.status peer-reviewed

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