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Browsing 4i - Centre for Interventions in Infection, Inflammation & Immunity by Title

Browsing 4i - Centre for Interventions in Infection, Inflammation & Immunity by Title

Now showing items 84-103 of 107

A qualitative assessment of practitioner perspectives post-introduction of the first continuous professional competence (CPC) guidelines for emergency medical technicians in Ireland.

Knox, Shane; Dunne, Suzanne S.; Cullen, Walter; Dunne, Colum P. (BioMed Central, 2015)

Background: In November 2013, the Irish Regulator for emergency medical technicians (EMTs) introduced the first mandatory requirement for registrants to demonstrate evidence of continuous professional development ...
Raman spectroscopic analysis of fingernail clippings can help differentiate between postmenopausal women who have and have not suffered a fracture

Beattie, James R.; Cummins, Niamh M.; Caraher, Clare; O'Driscoll, Olive M.; Bansal, Aruna T.; Eastell, Richard; Ralston, Stuart H.; Stone, Michael D.; Pearson, Gill; Towler, M.R. (Libertas Academica, 2016)

Raman spectroscopy was applied to nail clippings from 633 postmenopausal British and Irish women, from six clinical sites, of whom 42% had experienced a fragility fracture. The objective was to build a prediction algorithm ...
Raman spectroscopy predicts the link between claw keratin and bone collagen structure in a mouse model of oestrogen deficiency

Caraher, Clare; Sophocleous, Antonia; Beattie, Renwick J.; O'Driscoll, Olive M.; Cummins, Niamh M.; Brennan, Orlaith; O'Brien, Fergal J.; Ralston, Stuart H.; Bell, Steven E.J.; Towler, M.R.; Idris, Aymen I. (Elsevier, 2018)

Osteoporosis is a common disease characterised by reduced bone mass and an increased risk of fragility fractures. Low bone mineral density is known to significantly increase the risk of osteoporotic fractures, however, the ...
Regulation and registration as drivers of continuous professional competence for Irish pre-hospital practitioners: a discussion paper.

Knox, Shane; Dunne, Suzanne S.; Hughes, M.; Cheeseman, S.; Dunne, Colum P. (Springer, 2016)

Background The Regulatory Body responsible for the registration of Irish pre-hospital practitioners, the Pre-Hospital Emergency Care Council (PHECC), identified the need to implement a continuing professional competence ...
Regulation of GLUT4 translocation in an in vitro cell model using postprandial human serum ex vivo

Cogan, Karl E.; Carson, Brian P.; Patel, Bijal; Amigo-Benavent, Miryam; Jakeman, Philip M.; Egan, Brendan (Wiley and Sons Ltd, 2019)

Individual amino acids, amino acid mixtures and protein hydrolysates stimulate glucose uptake in many experimental models. To replicate better in vitro the dynamic postprandial response to feeding in vivo, in the present ...
Repeatability of two-dimensional chemical shift imaging multivoxel proton magnetic resonance spectroscopy for measuring human cerebral choline-containing compounds

Puri, Basant K.; Egan, Mary; Wallis, Fintan; Jakeman, Philip M. (Baishideng Publishing Group, 2018)

AIM To investigate the repeatability of proton magnetic resonance spectroscopy in the in vivo measurement of human cerebral levels of choline-containing compounds (Cho). METHODS Two consecutive scans were carried out ...
Research confuses me: what is qualitative research & what is the difference between grounded theory and phenomenology?

O'Gorman, Clodagh S.; Macken, Alan P.; Cullen, Walter; Saunders, Jean; Dunne, Colum P.; Higgins, M.F. (Irish Medical Organization, 2013)

What is qualitative research? Are there different types of qualitative research? Is qualitative research important in medicine? Is it not enough for me to understand quantitative research and its methodology? It is ...
Research confuses me: what is the difference between case-control and cohort studies in quantitative research?

Higgins, M.F.; Macken, Alan P.; Cullen, Walter; Saunders, Jean; Dunne, Colum P.; O'Gorman, Clodagh S. (Irish Medical Organization, 2013)

What is the difference between a cohort and a case-control trial? And why is it important? As a student, it is sometimes difficult to appreciate the difference between these two study methods, and why should it matter ...
A review of the differences and similarities between generic drugs and their originator counterparts, including economic benefits associated with usage of generic medicines, using Ireland as a case study

Dunne, Suzanne S.; Shannon, Bill; Dunne, Colum P.; Cullen, Walter (BioMed Central, 2013)

Generic medicines are those where patent protection has expired, and which may be produced by manufacturers other than the innovator company. Use of generic medicines has been increasing in recent years, primarily as a ...
Role of circulating ﬁbrocytes in the diagnosis of acute appendicitis

Zarog, M. A.; O'Leary, D. P.; Kiernan, M. G.; Bolger, J.; Tibbitts, P.; Coffey, S. N.; Lowery, A.; Byrnes, G. J.; Peirce, C.; Dunne, Colum P.; Coffey, J. C. (Wiley, 2020)

Background: Improved diagnostic biomarkers are required for acute appendicitis. The circulating fibrocyte percentage (CFP) is increased in inflammatory states, but has not been studied in acute appendicitis. This study ...
Sex differences in the temporal recovery of neuromuscular function following resistance training in resistance trained men and women 18 to 35 Years

Davies, Robert W.; Carson, Brian P.; Jakeman, Philip M. (Frontiers Media, 2018)

To investigate sex differences in the temporal recovery of neuromuscular function following resistance training (RT), eleven men and eight women 18–35 years completed a single RT bout (barbell back-squats, 80 % 1RM, 5 sets ...
Sleep-wake cycle disturbances in elderly acute general medical inpatients: longitudinal relationship to delirium and dementia.

Fitzgerald, James M; O'Regan, Niamh A.; Adamis, Dimitrios; Timmons, Suzanne; Dunne, Colum P.; Trzepacz, Paula T.; Meagher, David (Elsevier, 2017)

Introduction: Sleep disturbances in elderly medical inpatients are common, but their relationship to delirium and dementia has not been studied. Methods: Sleep and delirium status were assessed daily for a week in 145 ...
Specialised cleaning associated with antimicrobial coatings for reduction of hospital acquired infection. Opinion of the COST Action Network AMiCI (CA15114)

Dunne, Suzanne S.; Ahonen, Merja; Modic, Martina; Crijns, Francy R.L.; Keinänen-Toivola, Minna M.; Meinke, Ruth; Keevil, William C.; Gray, Jim; O'Connell, Nuala H.; Dunne, Colum P. (Elsevier, 2018)

Recognized issues with poor hand hygiene compliance among healthcare workers and reports of recontamination of previously chemically disinfected surfaces through hand contact emphasize the need for novel hygiene methods ...
Subsyndromal delirium compared to delirium, dementia, and subjects without delirium or dementia in elderly general hospital admissions and nursing home residents

Sepulveda, Esteban; Leonard, Maeve; Franco, José G; Adamis, Dimitrios; McCarthy, Geraldine; Dunne, Colum P.; Trzepacz, Paula T.; Gaviria, Ana M; de Pablo, Joan; Vilella, Elisabet; Meagher, David (Elsevier, 2017)

Introduction: Subsyndromal delirium (SSD) complicates diagnosis of delirium and dementia, although there is little research comparing their symptom profiles. Methods: Cross-sectional study of 400 elderly patients’ admission ...
Systemic molecular mediators of inflammation differentiate Between crohn’s disease and ulcerative colitis, implicating threshold levels of IL-10 and relative ratios of pro-inflammatory cytokines in therapy

Kiernan, Miranda G.; Coffey, Calvin J.; Sahebally, Shaheel M.; Tibbitts, Paul; Lyons, Emma May; O’Leary, Eimear; Owolabi, Funke; Dunne, Colum P. (Oxford University Press, 2019)

Background and Aims: Faecal diversion is associated with improvements in Crohn’s disease but not ulcerative colitis, indicating that differing mechanisms mediate the diseases. This study aimed to investigate levels of ...
Unprecedented reduction in births of very low birthweight (VLBW) and extremely low birthweight (ELBW) infants during the COVID-19 lockdown in Ireland: a ‘natural experiment’ allowing analysis of data from the prior two decades

Philip, Roy K.; Purtill, Helen; Reidy, Elizabeth; Daly, Mandy; Imcha, Mendinaro; McGrath, Deirdre; O'Connell, Nuala H; Dunne, Colum P. (BMJ, 2020)

Aetiology of births involving very low birthweight (VLBW) and extremely low birthweight (ELBW) infants is heterogeneous and preventive strategies remain elusive. Socioenvironmental measures implemented as Ireland’s ...
Validity of synthetic bone as a substitute for osteoporotic cadaveric femoral heads in mechanical testing: a biomechanical study

O'Neill, F.; Condon, F.; McGloughlin, Timothy M.; Lenehan, B.; Coffey, Calvin J.; Walsh, Michael T. (British Editorial Society of Bone and Joint Surgery, 2012)

IntroductionThe objective of this study was to determine if a synthetic bone substitute would provide results similar to bone from osteoporotic femoral heads during in vitro testing with orthopaedic implants. If the synthetic ...
What are the differences between a literature search, a literature review, a systematic review and a meta-analysis? And why is a systematic review considered to be so good?

O'Gorman, Clodagh S.; Macken, Alan P.; Cullen, Walter; Saunders, Jean; Dunne, Colum P.; Higgins, M.F. (Irish Medical Organization, 2013)

It takes time to recognise the differences between a literature search (LS), a literature review (LR), a systematic review (SR) and a meta-analysis (MA), especially as these terms are often used interchangeably by many ...
What are the differences between common statistical tests?

Higgins, M.F.; Macken, Alan P.; Cullen, Walter; Saunders, Jean; Dunne, Colum P.; O'Gorman, Clodagh S. (Irish Medical Organization, 2013)

Statistics are essential components of quantitative (and qualitative) research that we all should know. We have sat through numerous lectures on the subject, and we know that we need to understand it and really should ...
What do people really think about generic medicines? A systematic review and critical appraisal of literature on stakeholder perceptions of generic medicines.

Dunne, Suzanne S.; Dunne, Colum P. (BioMed Central, 2015)

Background: Considerable emphasis is presently being placed on usage of generic medicines by governments focussed on the potential economic benefits associated with their use. Concurrently, there is increasing discussion in ...

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