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Factors that affect mass transport from drug eluting stents into the artery wall

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Show simple item record O'Connell, Barry M McGloughlin, Timothy M. Walsh, Michael T. 2014-08-22T15:04:05Z 2014-08-22T15:04:05Z 2010
dc.description peer-reviewed en_US
dc.description.abstract Coronary artery disease can be treated by implanting a stent into the blocked region of an artery, thus enabling blood perfusion to distal vessels. Minimally invasive procedures of this nature often result in damage to the arterial tissue culminating in the re-blocking of the vessel. In an effort to alleviate this phenomenon, known as restenosis, drug eluting stents were developed. They are similar in composition to a bare metal stent but encompass a coating with therapeutic agents designed to reduce the overly aggressive healing response that contributes to restenosis. There are many variables that can influence the effectiveness of these therapeutic drugs being transported from the stent coating to and within the artery wall, many of which have been analysed and documented by researchers. However, the physical deformation of the artery substructure due to stent expansion, and its influence on a drugs ability to diffuse evenly within the artery wall have been lacking in published work to date. The paper highlights previous approaches adopted by researchers and proposes the addition of porous artery wall deformation to increase model accuracy. en_US
dc.language.iso eng en_US
dc.publisher BioMed Central en_US
dc.relation.ispartofseries BioMedical Engineering Online;9:15
dc.subject coronary artery disease en_US
dc.subject artery wall en_US
dc.title Factors that affect mass transport from drug eluting stents into the artery wall en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1186/1475-925X-9-15
dc.contributor.sponsor IRCSET en_US
dc.relation.projectid RS/2005/159 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US

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