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A bioactive metallurgical grade porous silicon-polytetrafluoroethylene sheet for guided bone regeneration applications

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dc.contributor.author Chadwick, Edward G.
dc.contributor.author Clarkin, O.M.
dc.contributor.author Raghavendra, Ramesh
dc.contributor.author Tanner, David A.
dc.date.accessioned 2014-08-18T13:07:50Z
dc.date.available 2014-08-18T13:07:50Z
dc.date.issued 2014
dc.identifier.uri http://hdl.handle.net/10344/3976
dc.description peer-reviewed en_US
dc.description.abstract The properties of porous silicon make it a promising material for a host of applications including drug delivery, molecular and cell-based biosensing, and tissue engineering. Porous Silicon has previously shown its potential for the controlled release of pharmacological agents and in assisting bone healing. Hydroxyapatite, the principle constituent of bone, allows osteointegration in vivo, due to its chemical and physical similarities to bone. Synthetic hydroxyapatite is currently applied as a surface coating to medical devices and prosthetics, encouraging bone in-growth at their surface & improving osseointegration. This paper examines the potential for the use of an economically produced porous silicon particulate-polytetrafluoroethylene sheet for use as a guided bone regeneration device in periodontal and orthopaedic applications. The particulate sheet is comprised of a series of microparticles in a polytetrafluoroethylene matrix and is shown to produce a stable hydroxyapatite on its surface under simulated physiological conditions. The microstructure of the material is examined both before and after simulated body fluid experiments for a period of 1, 7, 14 and 30 days using Scanning Electron Microscopy. The composition is examined using a combination of Energy Dispersive X-ray Spectroscopy, Thin film X-ray diffraction, Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy and the uptake/release of constituents at the fluid-solid interface is explored using Inductively Coupled Plasma-Optical Emission Spectroscopy. Microstructural and compositional analysis reveals progressive growth of crystalline, ´bone-like´ apatite on the surface of the material, indicating the likelihood of close bony apposition in vivo. en_US
dc.language.iso eng en_US
dc.publisher IOS Press en_US
dc.relation.ispartofseries Bio-Medical Materials and Engineering;24, pp. 1563-1574
dc.rights This is the author's version of a work that was published in Bio-Medical Materials and Engineering, 2014, 24, pp. 1563-1574, http://dx.doi.org/10.3233/BME-140961 en_US
dc.subject porous silicon (PS) en_US
dc.subject metallurgical grade silicon (MGSi) en_US
dc.subject nanoporous silicon en_US
dc.subject nanosponge en_US
dc.subject porous structure en_US
dc.subject scanning electron microscopy (SEM) en_US
dc.subject energy dispersive Xray en_US
dc.subject spectroscopy (EDX); en_US
dc.subject hydroxyapatite (HA) en_US
dc.title A bioactive metallurgical grade porous silicon-polytetrafluoroethylene sheet for guided bone regeneration applications en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.3233/BME-140961
dc.contributor.sponsor EI en_US
dc.contributor.sponsor PRTLI cycle 4 en_US
dc.contributor.sponsor Waterford Institute of Technology's South Eastern Applied Research Centre en_US
dc.relation.projectid EIIP 2007 0380 Vesta/ UL en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US


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