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Statistical tests for the detection of single nucleotide polymorphisms using DNA pooling

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Show simple item record Ramsey, David Futschik, Andreas 2014-07-22T13:57:53Z 2014-07-22T13:57:53Z 2011
dc.description peer-reviewed en_US
dc.description.abstract An important problem in genetics is detecting single nucleotide polymorphisms (SNPs), sites along the genome at which a population shows variation. The focus is on the detection of rare variants. Pooling individuals allows us to increase the probability that a rare variant appears in the sample. However, as the pool size increases, the mean number of reads from an individual decreases, making it harder to distinguish reads of a rare variant from errors. This paper compares three statistical tests for detecting SNPs using data from pooled DNA samples. en_US
dc.language.iso eng en_US
dc.publisher Internaitonal Statistical Institute en_US
dc.relation.ispartofseries Proceedings of the 58th Wrold Statistics Congress of the International Statistical Institute;
dc.subject genetics en_US
dc.subject single nucleotide polymorphisms en_US
dc.subject SNPs en_US
dc.subject DNA pooling en_US
dc.title Statistical tests for the detection of single nucleotide polymorphisms using DNA pooling en_US
dc.type info:eu-repo/semantics/conferenceObject en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.contributor.sponsor SFI en_US
dc.relation.projectid 07/MI012 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US

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