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The components of variance and the critical difference in specific markers of bone turnover in healthy adult males and postmenopausal women.

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dc.contributor.author Carroll, P.
dc.contributor.author Hunter, A.
dc.contributor.author Barry, D.
dc.contributor.author Barrett, E.
dc.contributor.author Loughnane, M.
dc.contributor.author Donnelly, R.
dc.contributor.author Murphy, N.
dc.contributor.author Jakeman, Philip M.
dc.date.accessioned 2014-05-28T09:28:56Z
dc.date.available 2014-05-28T09:28:56Z
dc.date.issued 2002
dc.identifier.citation Carroll, P; Hunter, A; Barry, D; Barrett, E; Loughnane, M; Donnelly, R; Murphy, N; Jakeman, PM (2002) 'The components of variance and the critical difference in specific markers of bone turnover in healthy adult males and postmenopausal women'. National Institute of Health Sciences Research Bulletin, 1 (4):41-42. en_US
dc.identifier.uri http://hdl.handle.net/10344/3837
dc.description peer-reviewed en_US
dc.description.abstract The study outlined here is part of an overall project, which aims to identify the optimum marker of bone resorption for both healthy young males and post-menopausal, non-osteoporotic women, and is as yet ongoing1. The purpose of this investigation was to quantify the components of variance in specific biochemical markers of bone turnover in healthy males and post-menopausal women i.e. total (CVS), analytical (CVA), within-subject biological (CVI) and betweensubject (CVG) variances. Using CVA and CVI for each individual, the individual critical difference (CDI) or least significant change (P<0.05) was calculated as previously described2. This value represents the minimal difference between two measurements of a biochemical marker that indicates a medically significant alteration of homeostasis (and is not due to normal biological and/or analytical variability alone). Given the CD of these markers the viability of using them in the assessment and/or monitoring of bone metabolism will be considered. en_US
dc.language.iso eng en_US
dc.publisher National Institute of Health Sciences en_US
dc.relation.ispartofseries National Institute of Health Sciences Research Bulletin;1 (4), pp.44-45
dc.subject bone resorption en_US
dc.title The components of variance and the critical difference in specific markers of bone turnover in healthy adult males and postmenopausal women. en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.date.updated 2014-05-28T09:14:12Z
dc.description.version PUBLISHED
dc.contributor.sponsor EI en_US
dc.relation.projectid SC/97/228 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1116534
dc.internal.copyrightchecked Yes
dc.description.status n/a


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