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Regional grey and white matter volumetric changes in myalgic encephalomyelitis (chronic fatigue syndrome): a voxel-based morphometry 3 T MRI study

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dc.contributor.author Puri, Basant K.
dc.contributor.author Jakeman, Philip M.
dc.contributor.author Agour, M.
dc.contributor.author Gunatilake, K.D.R.
dc.contributor.author Fernando, K.A.C.
dc.contributor.author Gurusinghe, A.I.
dc.contributor.author Treasaden, I.H.
dc.contributor.author Waldman, A.D.
dc.contributor.author Gishen, P.
dc.date.accessioned 2014-05-13T10:58:55Z
dc.date.available 2014-05-13T10:58:55Z
dc.date.issued 2012
dc.identifier.citation Puri, BK,Jakeman, PM,Agour, M,Gunatilake, KDR,Fernando, KAC,Gurusinghe, AI,Treasaden, IH,Waldman, AD,Gishen, P (2012) 'Regional grey and white matter volumetric changes in myalgic encephalomyelitis (chronic fatigue syndrome): a voxel-based morphometry 3 T MRI study'. British Journal Of Radiology, 85 :270-273. en_US
dc.identifier.uri http://hdl.handle.net/10344/3816
dc.description peer-reviewed en_US
dc.description.abstract Objective: It is not established whether myalgic encephalomyelitis/chronic fatigue syndrome (CFS) is associated with structural brain changes. The aim of this study was to investigate this by conducting the largest voxel-based morphometry study to date in CFS.Methods: High-resolution structural 3 T cerebral MRI scanning was carried out in 26 patients with CFS and 26 age-and gender-matched healthy volunteers. Voxel-wise generalised linear modelling was applied to the processed MR data using permutation-based non-parametric testing, forming clusters at t>2.3 and testing clusters for significance at p<0.05, corrected for multiple comparisons across space.Results: Significant voxels (p<0.05, corrected for multiple comparisons) depicting reduced grey matter volume in the CFS group were noted in the occipital lobes (right and left occipital poles; left lateral occipital cortex, superior division; and left supracalcrine cortex), the right angular gyrus and the posterior division of the left parahippocampal gyrus. Significant voxels (p<0.05, corrected for multiple comparisons) depicting reduced white matter volume in the CFS group were also noted in the left occipital lobe.Conclusion: These data support the hypothesis that significant neuroanatomical changes occur in CFS, and are consistent with the complaint of impaired memory that is common in this illness; they also suggest that subtle abnormalities in visual processing, and discrepancies between intended actions and consequent movements, may occur in CFS. en_US
dc.language.iso eng en_US
dc.publisher British Institute of Radiology en_US
dc.relation.ispartofseries British Journal of Radiology;85, pp. 270-273
dc.relation.uri http://dx.doi.org/10.1259/bjr/93889091
dc.rights © The British Institute of Radiology
dc.subject angular gyrus en_US
dc.subject images en_US
dc.title Regional grey and white matter volumetric changes in myalgic encephalomyelitis (chronic fatigue syndrome): a voxel-based morphometry 3 T MRI study en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.date.updated 2014-05-13T10:37:50Z
dc.description.version PUBLISHED
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1388086
dc.internal.copyrightchecked Yes
dc.description.status peer-reviewed


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