Browsing University Support Services by Subject "apoptosis"

Now showing items 1-2 of 2

Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: a potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c release.

Slee, Elizabeth A.; Keogh, Sinéad A.; Martin, Seamus J. (Nature Publishing Group, 2000)

BID, a pro-apoptotic Bcl-2 family member, promotes cytochrome c release during apoptosis initiated by CD95L or TNF. Activation of caspase-8 in the latter pathways results in cleavage of BID, translocation of activated ...
Failure of Bcl-2 to block cytochrome c redistribution during TRAIL-induced apoptosis

Keogh, Sinéad A.; Walczak, Henning; Bouchier-Hayes, Lisa; Martin, Seamus J. (Elsevier, 2000)

Tumour necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) is a member of the TNF family of cytokines that promotes apoptosis and NF-kB activation. Here we show that recombinant hu-TRAIL initiates the activation ...

DSpace Repository