Browsing University of Limerick Administration & Support Offices by Author "Slee, Elizabeth A."

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Cleavage of BID during cytotoxic drug and UV radiation-induced apoptosis occurs downstream of the point of Bcl-2 action and is catalysed by caspase-3: a potential feedback loop for amplification of apoptosis-associated mitochondrial cytochrome c release.

Slee, Elizabeth A.; Keogh, Sinéad A.; Martin, Seamus J. (Nature Publishing Group, 2000)

BID, a pro-apoptotic Bcl-2 family member, promotes cytochrome c release during apoptosis initiated by CD95L or TNF. Activation of caspase-8 in the latter pathways results in cleavage of BID, translocation of activated ...

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