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Personality, socio-economic status and inflammation: cross-sectional, population-based study

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dc.contributor.author Millar, Keith
dc.contributor.author Lloyd, Suzanne M.
dc.contributor.author McLean, Jennifer S.
dc.contributor.author Batty, David G.
dc.contributor.author Burns, Harry
dc.contributor.author Cavanagh, Jonathan
dc.contributor.author Deans, Kevin A.
dc.contributor.author Ford, Ian
dc.contributor.author McConnachie, Alex
dc.contributor.author McGinty, Agnes
dc.contributor.author Mottus, Réne
dc.contributor.author Packard, Chris J.
dc.contributor.author Sattar, Naveed
dc.contributor.author Shiels, Paul G.
dc.contributor.author Nathan, Yoga
dc.contributor.author Tannahill, Carol
dc.date.accessioned 2014-04-07T08:49:42Z
dc.date.available 2014-04-07T08:49:42Z
dc.date.issued 2013
dc.identifier.uri http://hdl.handle.net/10344/3767
dc.description peer-reviewed en_US
dc.description.abstract Background: Associations between socio-economic status (SES), personality and inflammation were examined to determine whether low SES subjects scoring high on neuroticism or hostility might suffer relatively higher levels of inflammation than affluent subjects. Methods: In a cross-sectional design, 666 subjects were recruited from areas of high (most deprived – ‘‘MD’’) and low (least deprived – ‘‘LD’’) deprivation. IL-6, ICAM-1, CRP and fibrinogen were measured along with demographic and healthbehaviour variables, and personality traits of neuroticism, extraversion and psychoticism (hostility). Regression models assessed the prediction of inflammation as a function of personality, deprivation and their interaction. Results: Levels of CRP and IL-6 were an increasing function of neuroticism and extraversion only in LD subjects opposite trends were seen in MD subjects. The result was ascribed parsimoniously to an inflammatory ceiling effect or, more speculatively, to SES-related health-behaviour differences. Psychoticism was strongly associated with ICAM-1 in both MD and LD subjects. Conclusions: The association between neuroticism, CRP and IL-6 may be reduced in MD subjects confirming speculation that the association differs across population sub-groups. The association between psychoticism and ICAM-1 supports evidence that hostility has adverse effects upon the endothelium, with consequences for cardiovascular health. Health interventions may be more effective by accounting for personality-related effects upon biological processes. en_US
dc.language.iso eng en_US
dc.publisher Public Library of Science en_US
dc.relation.ispartofseries PLOS one;8 (3), e58256
dc.relation.uri http://dx.doi.org/10.1371/journal.pone.0058256
dc.subject socio-economic status en_US
dc.subject neuroticism en_US
dc.title Personality, socio-economic status and inflammation: cross-sectional, population-based study en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1371/journal.pone.0058256
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US
dc.internal.rssid 1437761


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