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3D-Printed tissue-mimicking phantoms for medical imaging and computational validation applications

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Show simple item record Cloonan, Aidan J. Shahmirzadi, Danial Li, Ronny X. Doyle, Barry J. Konofagou, Elisa E. 2014-04-03T15:09:53Z 2014-04-03T15:09:53Z 2014
dc.identifier.citation 3D-Printed Tissue-Mimicking Phantoms for Medical Imaging and Computational Validation Applications. Aidan J. Cloonan, Danial Shahmirzadi, Ronny X. Li, Barry J. Doyle, Elisa E. Konofagou, Tim M. McGloughlin. 3D Printing and Additive Manufacturing. March 2014, 1(1): 14-23. en_US
dc.description peer-reviewed en_US
dc.description.abstract Abdominal aortic aneurysm (AAA) is a permanent, irreversible dilation of the distal region of the aorta. Recent efforts have focused on improved AAA screening and biomechanics - based failure prediction. Idealized and patient - specific AAA phantoms are often employed to validate numerical models and imaging modalities. To produce such phantoms, the investment casting process is frequently used, reconstructing the 3D vessel geometry from computed tomography patient scans. In this study the alternative use of 3D printing to produce phantoms is investigated. The mechanical properties of flexible 3D - printed materials are benchmarked against proven elastomers. We demonstrate the utility of this process with particular application to the emerging imaging modality of ultrasound - based pulse wave imaging, a noninvasive diagnostic methodology being developed to obtain regional vascular wall stiffness properties, differentiating normal and pathologic tissue in vivo . Phantom wall displacements under pulsatile loading conditions were observed, showing good correlation to fluid – structure interaction simulations and regions of peak wall stress predicted by finite element analysis. 3D - printed phantoms show a strong potential to improve medical imaging and computational analysis, potentially helping bridge the gap between experimental and clinical diagnostic tools. en_US
dc.language.iso eng en_US
dc.publisher Mary Ann Liebert, Inc. en_US
dc.relation.ispartofseries 3D Printing and Additive Manufacturing;1/1
dc.rights This is a copy of an article published in 3D Printing and Additive Manufacturing © 2014 Mary Ann Liebert, Inc.; 3D Printing and Additive Manufacturing is available online at: en_US
dc.subject abdominal aortic aneurysm en_US
dc.subject 3D printing en_US
dc.subject pulse wave imaging en_US
dc.subject Sylgard en_US
dc.subject HeartPrint Flex en_US
dc.subject TangoPlus FLX930 en_US
dc.subject Rupture prediction en_US
dc.subject computational en_US
dc.subject experimental en_US
dc.title 3D-Printed tissue-mimicking phantoms for medical imaging and computational validation applications en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.identifier.doi 10.1089/3dp.2013.0010
dc.contributor.sponsor Programme for Research in Third Level Institutions, Cycle 5, National Development Plan 2007 – 2013, with the assistance of the European Regional Development fund. en_US
dc.contributor.sponsor National Institutes of Health en_US
dc.contributor.sponsor SFI en_US
dc.relation.projectid 12 / RI / 2345(11) en_US
dc.relation.projectid R01 - HL098830 en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US

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