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Genetic pre-determinants of concurrent alcohol and opioid dependence: a critical review

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Show simple item record Martin, Marissa Klimas, Jan Dunne, Colum P. Meagher, David O'Connor, William T. O'Dwyer, Patrick Smyth, Bobby P. Cullen, Walter 2014-03-05T16:59:03Z 2014-03-05T16:59:03Z 2013
dc.identifier.citation Martin M, Klimas J, Dunne C, Meagher D, O'Connor WT, O Dwyer P, Smyth BP, Cullen W. Genetic pre-determinants of concurrent alcohol and opioid dependence: A critical review. OA Alcohol 2013 Nov 01;1(2):18. en_US
dc.description peer-reviewed en_US
dc.description.abstract Concurrent alcohol dependence poses a significant burden to health and wellbeing of people with established opioid dependence. Although previous research indicates that both genetic and environmental risk factors contribute to the development of drug or alcohol dependence, the role of genetic determinants in development of concurrent alcohol and opioid dependence has not been scrutinised. To search for genetic pre-determinants of concurrent alcohol and opioid dependence, electronic literature searches were completed using MEDLINE (PubMed) and EBSCO (Academic Search Complete) databases. Reference lists of included studies were also searched. In this discussion paper, we provide an overview of the genes (n=33) which are associated with the opioid, serotonergic, dopaminergic, GABA-ergic, cannabinoid, and metabolic systems for each dependency (i.e., alcohol or opioid) separately. The current evidence base is inconclusive regarding an exclusively genetic pre-determinant of concurrent alcohol and opioid dependence. Further search strategies and original research are needed to determine the genetic basis for concurrent alcohol and opioid dependency. en_US
dc.language.iso eng en_US
dc.publisher Open Access Publishing London en_US
dc.relation.ispartofseries OA Alcohol;Nov 01: 1(2):18
dc.rights The final HTML/PDF is also available at en_US
dc.subject addiction en_US
dc.title Genetic pre-determinants of concurrent alcohol and opioid dependence: a critical review en_US
dc.type info:eu-repo/semantics/article en_US
dc.type.supercollection all_ul_research en_US
dc.type.supercollection ul_published_reviewed en_US
dc.rights.accessrights info:eu-repo/semantics/openAccess en_US

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